HPV E6/E7、E5及E2蛋白与宫颈癌的关系研究进展  

Research progress on the relationship of human papillomavirus E6/E7,E5 and E2 proteins with cervical cancer

作　　者：孟斐[1] MENG Fei(Department of Obstetrics and Gynecology,The Central Hospital Affiliated to Shenyang Medical College,Shenyang 110024,China)

机构地区：[1]沈阳医学院附属中心医院妇产科,辽宁沈阳110024

出　　处：《沈阳医学院学报》2020年第4期289-293,共5页Journal of Shenyang Medical College

基　　金：辽宁省自然科学基金(No.2014020127)。

摘　　要：宫颈癌是妇科最常见的恶性肿瘤,严重威胁女性的身心健康。德国学者Harald首先提出了人乳头瘤病毒(HPV)与宫颈癌的关系,这使宫颈癌成为唯一具有明确病因的癌症,同时我们可以有针对性地对宫颈癌进行预防和治疗。目前发现的HPV种类约有160多种,其中13~15种与宫颈鳞状上皮内瘤变及宫颈癌有关,随着研究进展可知,HPV早期区的E1~E7基因及其编码的蛋白是病毒入侵宿主细胞,使宿主细胞转化及癌变的重要因素,故对E1~E7功能的阐明对明确宫颈癌的发病机制有重要影响。Cervical cancer is the most common malignant tumor in gynecology,which is a serious threat to women′s physical and mental health.German scholar Harald first proposed the relationship between human papillomavirus(HPV)and cervical cancer,which makes cervical cancer the only cancer with a clear cause.We can carry out targeted prevention and treatment of cervical cancer.There are about more than 160 types of HPV,of which 13-15 species are associated with cervical squamous intraepithelial neoplasia and cervical cancer.The early genes E1-E7 and their encoding proteins are important factors for HPV to invade host cells and make cells transform and become cancerous.Therefore,the clarification of the functions of E1-E7 is indispensable to make clear the pathogenesis of cervical cancer.

关 键 词：宫颈癌 发病机制 HPV E6/E7 HPV E2 HPV E5 

分 类 号：R737.3[医药卫生—肿瘤]