2个氨基膦酸酯类化合物的合成和抑菌活性研究  

Study on the synthesis of two phosphonates and the antimicrobial activity

作　　者：冯亚星 龚自伟 丁萌 徐畅 陈以 唐万侠[1] FENG Ya-xing;GONG Zi-wei;DING Meng;XU Chang;CHEN Yi;TANG Wan-xia(College of Chemistry and Chemical Engineering,Qiqihar University,Heilongjiang Qiqihar 161006,China)

机构地区：[1]齐齐哈尔大学化学与化学工程学院,黑龙江齐齐哈尔161006

出　　处：《齐齐哈尔大学学报（自然科学版）》2020年第4期51-53,56,共4页Journal of Qiqihar University(Natural Science Edition)

基　　金：2019年齐齐哈尔大学生创新创业计划资助项目(201910232288);黑龙江省教育厅基本业务专项(LTSW201736);省优势特色学科专项项目(YSTSXK201846)。

摘　　要：基于Kabachnik-Fields反应,反应原料亚膦酸二乙酯、苯甲醛分别与苯胺和对甲苯胺在无催化剂和溶剂,一定反应时间和温度条件下,一锅法合成了2个氨基膦酸酯类化合物(1和2),利用1H-NMR,13C-NMR和IR对化合物1和2进行了结构鉴定,命名为二乙基[(苯基)(苯胺基)甲基]膦酸酯(1)和二乙基[(苯基)(对甲苯胺基)甲基]膦酸酯(2)。对所合成的化合物1和2分别做了抑菌活性研究,选取2种细菌(枯草芽孢杆菌和大肠杆菌),3种真菌(Fusarium oxysporum,Llyonectria destructans和Neocosmospora rubicola)。结果表明,化合物1和2在测试浓度范围内分别对上述细菌和真菌表现出不同程度的抑制作用。The synthesis of twoaminophosphonates(1 and 2)in the one-pot reaction process under catalyst-free and solvent-free conditions based on the reaction of Kabachnik-Fieldswasreported.About the synthetic materials,diethyl phosphonate,benzaldehyde,aniline,and p-aminotoluenewere selected.The structures of compounds 1 and 2 were elucidated by analysis the spectra of 1H-NMR,13C-NMR and IR,namely,diethyl[(benzyl)(anilino)methyl]phosphonate(1)and diethyl[(benzyl)(aminotoluene)methyl]phosphonate(2).Compounds 1 and 2 were tested for antimicrobial activity against bacteria(Bacillus subtilis and Escherichia coli)and fungus(Fusarium oxysporum,Llyonectria destructans and Neocosmospora rubicola).As the results,compounds 1 and 2 exhibited antimicrobial activity to the bacteria and fungus according to the test concentration range.

关 键 词：合成 氨基膦酸酯 抑菌活性 

分 类 号：O626.26[理学—有机化学]