参芪扶正注射液治疗晚期肺癌的疗效及对免疫功能、生活质量的影响  

Efficacy of Shenqi Fuzheng Injection in the treatment of advanced lung cancer and its impact on immune function and quality of life

作　　者：贾静 张立英 徐云霞[3] 高向群[1] 刘莎[1] 刘增娟[1] JIA Jing;ZHANG Li-ying;XU Yun-xia;GAO Xiang-qun;LIU Sha;LIU Zeng-juan(Department of Pharmacy,the Third Hospital of Shijiazhuang City,Shijiazhuang Hebei 050011;Department of Laboratory,Zhongjie Hospital,Bohai New District,Cangzhou Hebei 061000;Department of Nursing,General Hospital of Jizhong Energy Xingtai Mining Group Co.,Ltd.,Xingtai Hebei 054000)

机构地区：[1]河北省石家庄市第三医院药剂科,河北石家庄050011 [2]沧州渤海新区中捷医院检验科,河北沧州061000 [3]冀中能源邢台矿业集团有限责任公司总医院护理部,河北邢台054000

出　　处：《世界中西医结合杂志》2020年第6期1133-1135,1139,共4页World Journal of Integrated Traditional and Western Medicine

基　　金：2017年石家庄市科学技术研究与发展指导计划项目(171462393)。

摘　　要：目的探讨参芪扶正注射液治疗晚期非小细胞肺癌(NSCLC)的临床疗效及对免疫功能、生活质量的影响。方法选取收治的80例晚期NSCLC患者,随机分为研究组及对照组,两组各40例。对照组患者单纯采用GP方案(吉西他滨^+顺铂)化疗,研究组在对照组治疗基础上联合参芪扶正注射液治疗。比较两组患者的临床疗效,并发症发生情况,免疫功能(CD3^+、CD4^+、CD4^+/CD8^+),生活质量评分情况。结果两组患者治疗后总有效率比较差异无统计学意义(P>0.05)。研究组患者治疗后化疗不良反应改善情况、免疫功能及生活质量改善情况均显著优于对照组,差异有统计学意义(P<0.05)。结论参芪扶正注射液不仅可减轻晚期NSCLC患者化疗的不良反应,同时还可提高其免疫功能及预后,值得临床推广。Objective To investigate the clinical efficacy of Shenqi Fuzheng injection in the treatment of advanced non-small cell lung cancer(NSCLC)and its impact on its immune function and quality of life.Methods Eighty patients with advanced NSCLC were selected and randomly divided into a study group and a control group,40 cases each.The patients in the control group were treated with GP regimen(gemcitabine+cisplatin),and the study group was treated with Shenqi Fuzheng injection on the basis of the control group.The clinical efficacy,occurrence of complications,immune function(CD3^+,CD4^+,CD4^+/CD8^+)and quality of life scores were compared between the two groups.Results There was no statistically significant difference in the total effective rate between the two groups after treatment(P>0.05).The improvement of chemotherapy adverse reaction,immune function and quality of life in the study group were significantly better than those in the control group,the difference was statistically significant(P<0.05).Conclusion Shenqi Fuzheng injection can not only reduce the adverse reactions of chemotherapy in patients with advanced NSCLC,but also improve its immune function and prognosis.It is worthy of clinical promotion.

关 键 词：参芪扶正注射液 晚期肺癌 免疫功能 生活质量 

分 类 号：R734.2[医药卫生—肿瘤]