富马酸喹硫平片联合碳酸锂对双相情感障碍躁狂发作患者认知功能的影响  

Effects of quetiapine fumarate combined with lithium carbonate on cognitive function in patients with bipolar disorder manic episode

作　　者：王冲[1] 李莹[1] 曹蕊 WANG Chong;LI Ying;CAO Rui(Department of Psychiatry,Zhumadian Psychiatric Hospital,Zhumadian 463000,China)

机构地区：[1]驻马店市精神病医院精神科,河南驻马店463000

出　　处：《黑龙江医药科学》2020年第2期41-42,共2页Heilongjiang Medicine and Pharmacy

摘　　要：目的:探究富马酸喹硫平片联合碳酸锂对双相情感障碍躁狂发作患者认知功能的影响及安全性评价。方法:选取我院精神科收治的双相情感障碍躁狂发作患者130例作为研究对象,随机将其分为2组。对照组(n=65)给予碳酸锂治疗,治疗组(n=65)在此基础上给予富马酸喹硫平片治疗。比较2组BRMS评分、CPT值、WCST值及HVLTR值变化;观察2组患者不良反应情况。结果:治疗组BRMS评分比对照组更低(P<0.01);CPT值明显高于对照组(P<0.01);2组头晕、头痛、嗜睡等不良反应经比较无显著差异(P>0.05)。结论:富马酸喹硫平片与碳酸锂改善双相情感障碍患者躁狂症状,提高患者注意力,且用药安全。Objective:To study the efficacy and safety of quetiapine fumarate combined with lithium carbonate in the treatment of cognitive function in bipolar disorder patients with manic episode.Methods:A total of 130 patients with bipolar disorder with manic episodes admitted to the psychiatric department of zhumadian psychiatric hospital were randomly divided into two groups with 65 cases each.The control group was treated with lithium carbonate,and the treatment group was treated with quetiapine fumarate tablet on the basis of the control group.BRMS score,CPT,WCST and HVLTR were compared between the two groups.The adverse reactions of the two groups were observed.Results:The BRMS score of the treatment group was significantly lower than that of the control group,and the CPT value was significantly higher than that of the control group,the difference was statistically significant(P<0.01).There was no statistically significant difference in the occurrence of adverse reactions such as dizziness,headache and drowsiness between the two groups(P>0.05).Conclusion:Quetiapine fumarate and lithium carbonate can effectively improve the symptoms of mania in patients with bipolar disorder.

关 键 词：富马酸喹硫平片 碳酸锂 双相情感障碍 躁狂 

分 类 号：R749[医药卫生—神经病学与精神病学]