阿司匹林在成人缺血型烟雾病血管重建术后的应用  

Application of aspirin after revascularization in adult patients with ischemic moyamoya disease

作　　者：吴勇[1] 黄书岚[1] 徐海涛[1] 朱晓楠[1] 陶祥[1] 观龙彬 容嘉彬 WU Yong;HUANG Shu-lan;XU Hai-tao;ZHU Xiao-nan;TAO Xiang;Guan Long-bin;RONG Jia-bin(Department of Neurosurgery,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院神经外科,武汉430060

出　　处：《中国临床神经外科杂志》2020年第7期421-423,共3页Chinese Journal of Clinical Neurosurgery

摘　　要：目的探讨阿司匹林在成人缺血型烟雾病血管重建术后的应用效果。方法回顾性分析2017年10月至2019年10月收治的符合入选标准的81例成人缺血型烟雾病的临床资料。47例术后应用阿司匹林(观察组),34例未使用阿司匹林(对照组)。结果观察组吻合口通畅率(97.87%,46/47)与对照组(94.12%,32/34)无统计学差异(P>0.05)。术后3个月,观察组改良Rankin量表评分([1.38±1.05]分)明显低于对照组([1.88±1.01]分;P<0.05)。观察组术后短暂性脑缺血发作发生率(4.26%)、脑梗死发生率(6.38%)均明显低于对照组(分别为23.53%、26.47%;P<0.05)。两组颅内出血、硬膜下血肿发生率均无统计学差异(P>0.05)。结论阿司匹林可减少成人缺血型烟雾病血管重建术后脑缺血事件,同时改善病人预后,并且不增加颅内出血风险。Objective To observe the clinical efficacy of aspirin after revascularization in adult patients with ischemic moyamoya disease.Methods The clinical data of 81 adult patients with ischemic moyamoya disease who underwent revascularization from October 2017 to October 2019 were analyzed retrospectively.The aspirin was used in 47 patients(observation group)and not in 34 patients(control group)after the operation.Results The incidence of transient ischemic attack(4.26%)and cerebral infarction(6.38%)in the observation group was significantly lower than those(23.53%and 26.47%,respectively)in the control group after the operation(P<0.05).The modified Rankin scale acore in the observation group(1.38±1.05)was significantly lower than that(1.88±1.01)in the control group after the operation(P<0.05).There was no significant sifference in postoperative anastomotic patency rate between both groups(P>0.05).Conclusion For adult patients with ischemic moyamoya disease undergoing revascularization,aspirin can reduce the probability of cerebral ischemic events after revascularization and improve the prognosis,and do not increase the risk of intracranial hemorrhage.

关 键 词：缺血型烟雾病 成人 血管重建术 阿司匹林 疗效 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R651.12[医药卫生—临床医学]