内型异莰烷基甲醛肟及其烷基醚的合成与抑菌活性  

Synthesis and antibacterial activity of Endo-isocamphanylformaldehyole oxime and its alkyl ether derivatives

作　　者：陶欣驰 冯雪贞 肖转泉[2] 范国荣[1] 王宗德[1] TAO Xin-chi;FENG Xue-zhen;XIAO Zhuan-quan;FAN Guo-rong;WANG Zhong-de(College of Forestry,Jiangxi Agricultural University,Nanchang 330027,China;College of Chemistry,Jiangxi Normal University,Nanchang 330027,China)

机构地区：[1]江西农业大学林学院,江西南昌330045 [2]江西师范大学化学化工学院,江西南昌330027

出　　处：《化学研究与应用》2020年第7期1176-1181,共6页Chemical Research and Application

基　　金：江西省重点研发计划项目(20192ACB60011)资助;国家“十三五”重点研发计划项目(2017YFD0600704)资助。

摘　　要：以内型异莰烷基甲醛与盐酸羟胺反应合成了内型异莰烷基甲醛肟,继而与卤代烃反应又得到5种内型异莰烷基甲醛肟烷基醚衍生物。所有6种化合物的结构通过GC-MS、1HNMR、13CNMR和IR分析方法进行表征。采用菌丝生长速率法,测试了6种化合物对12种植物病原真菌的抑菌活性。结果表明:所有的内型异莰烷基甲醛肟对12种植物病原真菌的生长有很好的抑制作用,所有内型异莰烷基甲醛肟烷基醚类化合物对6种植物病原真菌的生长也具有一定的抑制作用。Endo-isocamphanylformaldehyole oxime was synthesized by the reaction of endo-isocamphanylf-ormaldehyole with hydroxylamine hydrochloride.And then 5 endo-isocamphanylformaldehyole oxime alkyl ether derivatives were obtained by the reaction with halohydrocarbon.Structures of title compounds were confirmed by the metholds of GC-MS、1HNMR、13CNMR and IR.The mycelium growth rate method was used to test the effects of the 6 compounds on 12 plant pathogenic fungi.The results showed that all the endo-isocamphanylformaldehyole oxime had good inhibiting effects on the growth of 12 kinds of plant pathogenic fungi.And all the endo-isocamphanylformaldehyole oxime alkyl ether derivatives had some in hibiting effects on the growth of 6 kinds of plant pathogenic fungi.

关 键 词：内型异莰烷基甲醛肟 内型异莰烷基甲醛肟醚 合成 抑菌活性 

分 类 号：O621[理学—有机化学]