长春西汀联合依达拉奉对急性脑梗死患者血浆MMP-3、TNF-α、SOD、MDA水平的影响  

Effect of Vinpocetine combined with Edaravone on Plasma MMP-3, TNF-α, SOD and MDA levels in Patients with acute cerebral Infarction

作　　者：冯慧 FENG Hui(Department of Internal Medicine,Chiping County Third People's Hospital,Liaocheng Shandong 252100,China)

机构地区：[1]聊城市茌平区第三人民医院内科,山东聊城252100

出　　处：《临床研究》2020年第8期32-34,共3页Clinical Research

摘　　要：目的探讨长春西汀联合依达拉奉对急性脑梗死患者血浆MMP-3、TNF-α、SOD、MDA水平的影响,评价其应用价值。方法自聊城市茌平区第三人民医院2018年5月-2019年7月收治的ACI患者96例,按照随机数表法的原则将其进行分组,治疗组(48例)与对照组(48例)。对照组采用长春西汀,治疗组在此基础上应用依达拉奉。对比分析两组临床疗效,并治疗前、治疗后血浆炎性因子水平的变化情况。结果相比对照组,治疗组总临床疗效率更高,且治疗后,治疗组MMP-3、TNF-α、MDA低于对照组,SOD高于对照组,差异具有统计学意义(P<0.05)。结论为ACI患者给予长春西汀联合依达拉奉使用,临床应用确切,可有效促进炎症因子的释放,修复神经功能。Objective To investigate the effect of vinpocetine combined with edaravone on the plasma levels of MMP-3,TNF-α,Sod and MDA in patients with acute cerebral infarction,and evaluate its application value.Methods From May 2018 to July 2019,96 patients with ACI were divided into two groups according to the principle of random number table.The treatment group(48 cases)and the control group(48 cases).The control group was treated with vinpocetine,and the treatment group was treated with edaravone.The clinical effects of the two groups were compared and analyzed,and the changes of plasma inflammatory factors were observed before and after treatment.Results Compared with the control group,the total clinical efficacy of the treatment group was higher,and after treatment,MMP-3,TNF-α,MDA in the treatment group were lower than the control group,SOD was higher than the control group,the difference was statistically significant(P<0.05).Conclusion The combination of vinpocetine and edaravone in patients with ACI can effectively promote the release of inflammatory factors and repair nerve function.

关 键 词：急性脑梗死 长春西汀 依达拉奉 血浆炎症因子 

分 类 号：R743.3[医药卫生—神经病学与精神病学]