血清AGEs、sRAGE、SOD、MDA对血管性痴呆的辅助诊断价值  

Auxiliary diagnostic value of serum AGEs,sRAGE,SOD,MDA in vascular dementia

作　　者：卢军锋[1] 方芳[2] LU Junfeng;FANG Fang(Department of Emergency,Hangzhou Traditional Chinese Medicine Hospital,Hangzhou 310007,China;Department of Neurology,Hangzhou Traditional Chinese Medicine Hospital,Hangzhou 310007,China)

机构地区：[1]杭州市中医院急诊科,浙江杭州310007 [2]杭州市中医院神经内科,浙江杭州310007

出　　处：《中国现代医生》2020年第15期18-21,共4页China Modern Doctor

基　　金：浙江省中医药科技计划项目(2017ZB073)。

摘　　要：目的探讨血清AGEs、sRAGE、SOD、MDA对血管性痴呆的辅助诊断价值。方法选择2018年6月~2019年9月在我院诊断治疗的血管性痴呆患者30例为研究对象,另选择健康体检者30例为对照组。比较两组血清AGEs、sRAGE、SOD、MDA水平。绘制ROC曲线,用曲线下面积判断AGEs、sRAGE、SOD、MDA对血管性痴呆的辅助诊断价值。结果(1)血管性痴呆组SOD活性显著低于对照组,MDA水平显著高于对照组,差异有统计学意义(P<0.05);两组血清AGEs、sRAGE水平比较无统计学差异(P>0.05)。(2)AGEs对血管性痴呆的辅助诊断价值ROC曲线下面积AUC 0.490,无辅助诊断价值。(3)sRAGE对血管性痴呆的辅助诊断ROC曲线下面积AUC=0.508,无辅助诊断价值。(4)SOD活性对血管性痴呆的辅助诊断ROC曲线下面积AUC=0.833,具有较好的辅助诊断价值。以65.0 nU/mL为界值,灵敏度73.3%,特异度96.7%。(5)MDA对血管性痴呆的辅助诊断价值ROC曲线下面积0.905,具有较好的辅助诊断价值。以7.0 mol/mL为界值,灵敏度85.0%,特异度90.0%。结论血清AGEs、sRAGE水平对血管性痴呆无明确的辅助诊断价值,而SOD与MDA对血管性痴呆有一定的辅助诊断价值。Objective To explore the auxiliary diagnostic value of serum advanced glycation end products(AGEs),soluble receptor for advanced glycation end products(sRAGE),superoxide dismutase(SOD),and multiple ascending dose(MDA)in the vascular dementia.Methods 30 patients with vascular dementia diagnosed and treated in our hospital from June 2018 to September 2019 were selected as the study subjects,and 30 healthy people were selected as the control group.The serum AGEs,sRAGE,SOD,and MDA levels were compared between the two groups.The ROC curve was drawn,and the area under the curve was used to determine the auxiliary diagnostic value of AGEs,sRAGE,SOD,and MDA in vascular dementia.Results(1)The SOD activity in the vascular dementia group was significantly lower than that in the control group,and the MDA level was significantly higher than that in the control group,and the differences were statistically significant(P<0.05).There were no significant differences in serum AGEs and sRAGE between the two groups(P>0.05).(2)The area under the ROC curve(AUC)of AGEs for the auxiliary diagnosis of vascular dementia was 0.490,which had no auxiliary diagnostic value.(3)The AUC of sRAGE for the auxiliary diagnosis of vascular dementia was 0.508,which had no auxiliary diagnostic value.(4)The AUC of SOD activity for the auxiliary diagnosis of vascular dementia was 0.833,which had good auxiliary diagnostic value.Taking 65.0 nU/mL as the cut-off value,the sensitivity was 73.3%and the specificity was 96.7%.(5)The AUC of MDA for the auxiliary diagnosis of vascular dementia was 0.905,which had good auxiliary diagnostic value.Taking 7.0 mol/mL as the cut-off value,the sensitivity was 85.0%and the specificity was 90.0%.Conclusion Serum AGEs and sRAGE levels have no clear auxiliary diagnostic value for vascular dementia,while SOD and MDA have certain auxiliary diagnostic value for vascular dementia.

关 键 词：晚期糖基化终末产物 可溶性晚期糖基化终末产物特异性受体 超氧化物歧化酶 血管性痴呆 辅助诊断 

分 类 号：R749.1[医药卫生—神经病学与精神病学]