Neuroimaging and intervening in memory reconsolidation of human drug addiction  

作　　者：Chuan FAN Yan CHENG Huixing GOU Chang LIU Shengliang DENG Chialun LIU Xianwen CHEN Junjie BU Xiaochu ZHANG 

机构地区：[1]Department of Psychiatry,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,China [2]School of Life Science,Division of Life Science and Medicine,University of Science and Technology of China,Hefei 230026,China [3]Department of Neurology,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,China [4]School of Biomedical Engineering,Anhui Medical University,Hefei 230032,China [5]CAS Key Laboratory of Brain Function and Disease,University of Science and Technology of China,Hefei 230026,China

出　　处：《Science China(Information Sciences)》2020年第7期34-44,共11页中国科学（信息科学）（英文版）

基　　金：supported by National Key Basic Research Program(Grant Nos.2016YFA0400900,2018YFC0831101);National Natural Science Foundation of China(Grant Nos.71942003,31771221,61773360,71874170);School Foundation of Anhui Medical University(Grant Nos.2019xkj016,XJ201907);National Science Foundation for Young Scientists of China(Grant No.31900766);Major Project of Philosophy and Social Science Research,Ministry of Education of China(Grant No.19JZD010);Fundamental Research Funds for the Central Universities of China。

摘　　要：Reconsolidation refers to memory reprocessing when consolidated memory is being recalled and restored.Importantly,as memory is being recalled,it could further modify past memories.Memory reconsolidation has been identified as a critical role in various types of mental disorders,in particular drug addiction.In this review,we first review earlier studies related to reconsolidation.Secondly,we characterize memory reconsolidation processing in human brain via neuroimaging studies.Then we focus on the role of reconsolidation and reconsolidation-based interventions in drug addiction.Finally,we highlight the potentials of combining reconsolidation-based interventions and neuroimaging techniques as a therapeutic tool in drug addiction.

关 键 词：memory reconsolidation human neuroimaging drug addiction retrieval-extinction 

分 类 号：R749.64[医药卫生—神经病学与精神病学]