基于突触可塑性浅析中医“从肾论治”阿尔茨海默病  

Analysis of Alzheimer’s Disease“Treated from Kidney”in Traditional Chinese Medicine Based on Synaptic Plasticity

作　　者：吴东南[1] 刘玲[1] 丁瑞丛 杨希茜 王平[1] WU Dongnan;LIU Ling;DING Ruicong;YANG Xiqian;WANG Ping(Hubei University of Traditional Chinese Medicine,Wuhan 430065,Hubei,China)

机构地区：[1]湖北中医药大学,湖北武汉430065

出　　处：《辽宁中医杂志》2020年第4期95-97,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金(81273648)。

摘　　要：突触可塑性损伤是阿尔茨海默病(AD)重要的病理表现,是导致认知障碍重要的因素,是AD中枢神经退行性病变的具体体现。因此以突触可塑性为靶向的治疗给AD带来希望,但目前仍未取得实质性的进展。从中医的视角,肾精亏虚导致的髓减脑消是AD的基本病机,突触可塑性损伤是髓减脑消的表现,"从肾论治"AD能修复突触可塑性损伤,改善认知功能,推测"从肾论治"可能通过靶向修复突触可塑性损伤,但介导具体的作用机制还需进一步的研究。Synaptic plasticity injury is an important pathological manifestation of Alzheimer’s disease(AD),an important factor leading to cognitive impairmentand a specific manifestation of AD central nervous degeneration.Therefore,the treatment of targeting synaptic plasticity has brought hope to AD,but no substantial progress has been made so far.From the viewpoint of traditional Chinese medicine,brain deficiency caused by deficiency of kidney essence is the basic pathogenesis of AD and synaptic plasticity damage is the manifestation of brain deficiency.The treatment from kidneycan repair the damaged synaptic plasticityand improve cognitive function.Therefore,the treatment from kidney may through targeted repair damaged synaptic plasticity to achieve the effect,but the mechanism of mediating still needs further research.

关 键 词：阿尔茨海默病 突触可塑性 从肾论治 

分 类 号：R749.1[医药卫生—神经病学与精神病学]