线栓法制备MCAO大鼠模型过程中相关影响因素探析  

Analysis of Related Influencing Factors in Preparing MCAO Rat Model by Suture Method

作　　者：马雁鸿 蒋佳 刘蕾 周颖[1] 陈成[2] 潘江[2] 章薇[2] 娄必丹[2] MA Yanhong;JIANG Jia;LIU Lei;ZHOU Ying;CHEN Cheng;PAN Jiang;ZHANG Wei;LOU Bidan(Hunan University of Traditional Chinese Medicine,Changsha 410007,Hunan,China;The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine,Changsha 410007,Hunan,China)

机构地区：[1]湖南中医药大学,湖南长沙410007 [2]湖南中医药大学第一附属医院,湖南长沙410007

出　　处：《辽宁中医杂志》2020年第4期186-188,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金(81774421,81473754,81273861);湖南省自然科学基金项目(2018JJ2306,2018JJ3401)。

摘　　要：线栓法因具有不开颅、创伤小、重复性高、能准确控制缺血灶,模拟临床脑缺血的各种症状等优点,已成为制备MCAO大鼠模型最常用的方法。该法制备MCAO模型易受多种因素的制约,影响造模的成功率,且给模型的复制带来了较大的困难。文章就影响这一模型制备的各种因素作一个简单的探析。Because of the advantages of non-craniotomy,less trauma,high repeatability,accurate control of ischemic focus,and the simulation of various symptoms of clinical cerebral ischemia,the linear tethering method has become the most commonly-used method in the preparation of MCAO rat model.The preparation of MCAO model is easy to be restricted by many factors,affects the success rate of model making and brings great difficulty to model replication.This paper made a simple analysis of the factors influencing the preparation of the model.

关 键 词：线栓法 MCAO大鼠 相关影响因素 探析 

分 类 号：R-332[医药卫生]