结直肠黏液腺癌的研究进展  

Advances in study of colorectal mucinous adenocarcinoma

作　　者：秦秀森 过文泰 曹务腾[1] 王辉[1] QIN Xiusen;GUO Wentai;CAO Wuteng;WANG Hui(The Sixth Affiliated Hospital,Sun Yat-sen University&Guangdong Provincial Institute of Gastroenterology&Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease,Guangzhou 510655,P.R.China)

机构地区：[1]中山大学附属第六医院,广东省胃肠病研究所,广东省结直肠盆底疾病研究重点实验室,广州510655

出　　处：《中国普外基础与临床杂志》2020年第7期906-911,共6页Chinese Journal of Bases and Clinics In General Surgery

基　　金：广州市科技计划项目(编号:201704020059)。

摘　　要：目的总结结直肠黏液腺癌的研究进展。方法检索近年来国内外有关结直肠黏液腺癌研究的相关文献并对其研究进展进行综述。结果结直肠黏液腺癌是结直肠癌的一种病理学亚型,其具有独特的临床病理特点,发病率相对较低,但其与不良预后有关。目前研究认为,BRAF突变、微卫星不稳定、CpG岛甲基化及黏蛋白的表达与结直肠黏液腺癌的发生及发展有一定关系,但其分子机制仍不十分清楚。结直肠黏液腺癌多见于结肠近端,女性患者多见,多发转移、肝外及腹膜转移常见,术前MRI检查具有重要价值。治疗以手术治疗为主,对于进展期患者仍需要多学科联合讨论以制定最佳治疗方案。相比其他类型结直肠腺癌,结直肠黏液腺癌患者预后不良。结论目前虽然对结直肠黏液腺癌已经有了一定程度的了解,但由于较多相关研究的样本量较小且缺乏前瞻性的随机对照试验研究,因而研究结果存在一定的局限性,故未来仍需更多的研究来提高对结直肠黏液腺癌的认知,未来的研究应集中在结直肠黏液腺癌的分子机制及治疗方面。Objective To summarize the research progress of colorectal mucinous adenocarcinoma.Method The articles about colorectal mucinous adenocarcinoma in recent years were reviewed. Results The colorectal mucinous adenocarcinoma was a pathological subtype of colorectal cancer, which had unique clinicopathologic characteristics, relatively low incidence, and poor prognosis. The current studies suggested that the BRAF mutation,microsatellite instability, CpG island methylation, and mucin expression were related to the occurrence and development of colorectal mucinous adenocarcinoma, but its molecular mechanism was still unclear. The colorectal mucinous adenocarcinoma was more common in the proximal colon and female patients. The multiple metastases, extrahepatic and peritoneal metastases were also common. The preoperative MRI examination was very valuable. The main treatment was surgery, and the multidisciplinary discussions were still needed to determine the best treatment for patients in the advanced stage. Compared with other types of colorectal adenocarcinoma, patients with colorectal mucinous adenocarcinoma had a poor prognosis. Conclusions Although we have a certain understanding of colorectal mucinous adenocarcinoma, the study results are limited due to the small sample size of many related articles and the lack of prospective randomized controlled studies. Therefore, more studies are needed in the future to improve the cognition of colorectal mucinous adenocarcinoma. Future research should focus on the molecular mechanism and treatment of colorectal mucinous adenocarcinoma.

关 键 词：结直肠癌 黏液腺癌 发病机制 临床病理特点 

分 类 号：R735.34[医药卫生—肿瘤]