miRNA在老年性黄斑变性中的调控作用  

The regulation of miRNA in age-related macular degeneration

作　　者：刘晓晨 吴敏[1] Liu Xiaochen;Wu Min(Department of Ophthalmology,The Sceond People's Hospital of Yunnan Province,Yunnan Eye Institute,Key Laboratory of Yunnan Province for the Prevention and Treatment of Ophthalmology,Kunming 650021,China)

机构地区：[1]云南省第二人民医院眼科云南省眼科研究所云南省眼科疾病防治研究重点实验室,昆明650021

出　　处：《中华眼底病杂志》2020年第7期560-564,共5页Chinese Journal of Ocular Fundus Diseases

基　　金：云南省应用基础研究(昆医联合专项)(2017FE467(-195));云南省基础研究计划重点项目(2019FA028);云南省医学学科带头人培养计划(D2017-010)。

摘　　要：miRNA是一种性质稳定的小分子RNA,在动物、植物内大量表达,可通过与目的mRNA的3’非翻译区碱基互补配对结合,在转录后水平调控靶基因的表达。某些miRNA的表达失调及其后续的异常生物学调控,与老年性黄斑变性(AMD)发生发展中的炎症反应、氧化应激损伤、吞噬功能障碍以及异常血管生成方面有着密切联系。鉴于miR-155、miR-125b及miR-34a的失调似乎对AMD的发生起到了更加重要的作用,这些miRNA或有望成为AMD的诊断标记物及治疗新靶点。MiRNAs are stable small RNAs that are expressed abundantly in animals and plants.They can bind to the 3'-untranslated region of the target mRNA,and regulate its expression at the post-transcriptional level.The miRNAs'abnormal expression and its following abnormal biological regulation are closely related to the occurrence and development of age-related macular degeneration(AMD),including inflammatory response,oxidative stress injury,phagocytosis dysfunction and abnormal angiogenesis.Since the dysregulation of miR-155,miR-125b and miR-34a seems to play a more important role in AMD,these microRNAs may be expected to become the new biomarkers and therapeutic targets for AMD.

关 键 词：黄斑变性/病因学 微RNAS 氧化性应激 综述 

分 类 号：R774.5[医药卫生—眼科]