ADAS-Cog在我国老年人群中的结构效度  

Construct validity of Alzheimer’s disease assessment scale-cognitive subscale(ADAS-Cog)among Chinese older people

作　　者：蒋衍 程灶火 JIANG Yan;CHENG Zaohuo(Department of Clinical Psychology,the Affiliated Wuxi Mental Health Center of Nanjing Medical University,Wuxi,214151,China)

机构地区：[1]南京医科大学附属无锡精神卫生中心临床心理科,江苏无锡214151

出　　处：《南京医科大学学报（自然科学版）》2020年第5期732-736,共5页Journal of Nanjing Medical University(Natural Sciences)

基　　金：江苏省社会发展重点项目(BE2015615)。

摘　　要：目的:评估我国老年人群中的阿尔茨海默病疾病评估量表-认知子量表(Alzheimer’s disease assessment scale-cognitive subscale,ADAS-Cog)的结构效度。方法:收集628例正常对照,572例轻度认知障碍(mild cognitive impairment,MCI)和76例阿尔茨海默病(Alzheimer’s disease,AD),评估ADAS-Cog的结构效度。结果:ADAS-Cog在AD和MCI组的条目与总分相关系数分别在0.51~0.83和0.27~0.69之间。AD组的结构效度优于MCI组,但均较为一般。AD组的因子分析中得到记忆(包括单词回忆和单词辨认)和认知功能(其他所有项目)2个因子,解释63.23%的方差。MCI组提取出记忆(包括单词回忆和单词辨认)、语言(包括回忆测验、口头语言、找词困难和口语理解)、意象(包括物体命名和意象练习)和执行命令4个因子,累计方差解释率为68.02%。结论:ADAS-Cog在评估AD人群方面具有良好的条目相关性和结构效度,但在MCI人群上则较差。Objective:This study aims to evaluate the construct validity of the Alzheimer’s disease assessment scale-cognitive subscale(ADAS-Cog)among Chinese older people population.Methods:A total of 628 normal controls,572 patients with mild cognitive impairment(MCI)and 76 patients with Alzheimer’s disease(AD)were collected to assess the construct validity of ADASCog.Results:In general,the correlation coefficients between the scale and the total scores of ADAS-Cog in AD and MCI groups were between 0.51-0.83 and 0.27-0.69.The construct validity of AD group was better than that of MCI group,but all of them were not good enough.In the factor analysis of the AD group,two factors were analyzed:memory(including word recall and word recognition)and cognitive function(all other scales),which accounted for 63.23%of total variance.Four factors were extracted from the MCI group:memory(including word recall and word recognition),language(including recall of test instructions,spoken language ability,wordfinding difficulty and comprehension of spoken language),ideation(including naming objects and fingers and ideational praxis)and commands,with a cumulative variance interpretation rate of 68.02%.Conclusion:This study confirmed that ADAS-Cog had good item correlation and structural validity in evaluating AD population,but was poor in MCI population.

关 键 词：ADAS-COG 阿尔茨海默病 轻度认知障碍 效度 

分 类 号：R749.16[医药卫生—神经病学与精神病学]