自噬在视网膜母细胞瘤中的研究进展  

Advances in research of autophagy in retinoblastoma

作　　者：孙洁[1] 邵庆[1] 刘庆淮[1] SUN Jie;SHAO Qing;LIU Qinghuai(Department of Ophthalmology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学第一附属医院眼科,江苏南京210029

出　　处：《南京医科大学学报（自然科学版）》2020年第5期763-767,共5页Journal of Nanjing Medical University(Natural Sciences)

基　　金：国家自然科学基金(81672673)。

摘　　要：视网膜母细胞瘤(retinoblastoma,RB)是儿童最常见的原发性眼内恶性肿瘤。尽管近年来关于RB发病机理的研究逐渐深入,但仍保持较高的病死率,急需寻找更好的治疗策略。自噬是真核生物中高度保守的分解代谢过程。研究表明,自噬在RB疾病进展中起着至关重要的作用,有望成为RB治疗的新靶标。本文综述了自噬在RB疾病发展和治疗中的作用,为将来RB的临床治疗提供了新思路。Retinoblastoma(RB)is the most common ocular malignancy in children.Despite a recently enhanced understanding of the etiology of RB,the mortality associated with it remains high worldwide.Hence,it’s urgent to find better treatments.Autophagy is a highly conserved catabolism process in eukaryotes.Studies have shown that autophagy plays a crucial role in the progression of RB,and it is expected to become a new target for RB treatment.This article reviews the role of autophagy in the development and treatment of retinoblastoma,and provides new ideals for clinical treatment of RB.

关 键 词：自噬 视网膜母细胞瘤 

分 类 号：R739.72[医药卫生—肿瘤]