抗N-甲基-D-天冬氨酸受体脑炎五例临床分析  

Clinial analysis on five cases of anti N-methyl-D-asparate receptor encephalitis

作　　者：刘磊[1] 史冬梅[1] 唐晓梅[1] 冯浩[1] 杨兴东[1] 冯研[1] 张燕辉[1] 李群彦 于逢春[1] Liu Lei;Shi Dongmei;Tang Xiaomei;Feng Hao;Yang Xingdong;Feng Yan;Zhang Yanhui;Li Qunyan;Yu Fengchun(Department of Neurology,Beijing Haidian Hospital,Haidian Section of Peking University Third Hospital,Beijing 100080,China)

机构地区：[1]北京市海淀医院北京大学第三医院海淀院区神经内科,100080

出　　处：《北京医学》2020年第5期390-392,共3页Beijing Medical Journal

摘　　要：目的总结抗N-甲基-D-天冬氨酸受体(N-methyl-D-asparate receptor,NMDAR)脑炎的临床特点及治疗预表现、影像学、实验室检查、脑电图、治疗及预后,并结合文献进行分析。结果5例患者均有精神行为异常、脑脊液抗样,可复发,脑脊液抗NMDAR抗体阳性和临床症状是确诊该病的主要依据,临床需定期监测相关指标。Objective To summarize the clinical characteristics and prognosis of anti N-methyl-D-asparate receptor(NMDAR)encephalitis.Methods The clinical data of five confirmed patients were analyzed retrospectively,including clinical manifestations,imaging,laboratory examination,EEG,treatment,prognosis,and literatures were reviewed.Results All of the five patients had abnormal mental behavior with positive anti NMDAR antibody in cerebral spinal fluid(CSF),and one case relapsed.The prognosis was good after treatment with immunoglobulin and glucocorticoid.Conclusions The clinical manifestations of anti NMDAR encephalitis are complex and various,and it can recur.Positive NMDAR antibody in CSF and symptoms are the main basis for the diagnosis of the disease,and their relevant indexes need to be monitored regularly.

关 键 词：抗N-甲基-D-天冬氨酸受体脑炎 临床特征 复发 治疗 

分 类 号：R742.9[医药卫生—神经病学与精神病学]