p53在细胞增殖和迁移中对骨架重建的作用  

Role of p53 in Cytoskeletal Reconstruction during Cell Proliferating and Migrating

作　　者：闫婧伊 郝倩[1] 刘莹[1] 安输[1] 郭晓汐 徐天瑞[1] 杨洋[1] YAN Jingyi;HAO Qian;LIU Ying;AN Shu;GUO Xiaoxi;Xu Tianrui;YANG Yang(Faculty of Life Science and Technology,Kunming University of Science and Technology,University Based Provincial Key Laboratory of Screening and Utilization of Targeted Drugs,Kunming 650500,China)

机构地区：[1]昆明理工大学生命科学与技术学院云南省高校靶点药物筛选与利用重点实验室,昆明650500

出　　处：《中国细胞生物学学报》2020年第5期922-927,共6页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:81460417、31660099、81560455和81760264)资助的课题。

摘　　要：p53作为最重要的抑癌因子之一,通常作为转录因子发挥肿瘤抑制作用。除转录活性外,p53及其突变型可能通过调节整合素、钙黏蛋白、Rho/ROCK信号通路等对肌动蛋白细胞骨架重建产生作用,从而影响细胞增殖和迁移。p53的这些功能在调节肌动蛋白细胞骨架重建以响应细胞外微环境和癌基因激活中起着至关重要的作用。p53 is the most important tumor suppressor,and usually exerts tumor-suppressing effect as a transcription factor.Except for its transcriptional activity,p53 and its mutants may also have effects on cell proliferation and migration though other pathways,including integrin signaling,cadherin,and Rho/ROCK signaling.These multiple functions of p53 play crucial roles in regulating actin cytoskeletal reconstruction to respond to extracellular microenvironment and oncogene activation.

关 键 词：P53 细胞骨架 整合素 Rho/ROCK 钙黏蛋白 MIRNA 细胞迁移 

分 类 号：R730.2[医药卫生—肿瘤]