GL-V9 reverses adriamycin resistance in hepatocellular carcinoma cells by affecting JNK2-related autophagy  

作　　者：YANG Yue LIAO Yan GUI Yan-Ping ZHAO Li GUO Lu-Bo 

机构地区：[1]School of Basic Medicine and Clinical Pharmacology,China Pharmaceutical University,Nanjing 211100,China [2]Department of Pharmacy,Central Hospital Affiliated to Shandong First Medical University,Jinan 250013,China

出　　处：《Chinese Journal of Natural Medicines》2020年第7期491-499,共9页中国天然药物（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.81773774);“Double First-Class University Project” of China Pharmaceutical University(CPU.018GY37)。

摘　　要：Adriamycin resistance in HCC seriously hinders the treatment of patients,it is necessary to investigate the mechanisms.Autophagy is involved in adriamycin resistance and JNK2 is related to autophagy.However,whether JNK2 inducing drug resistance though autophagy is unknown.GL-V9,a new synthesized flavonoid derivative,has been proved of its anti-tumor effects.The aim of the study is to explore the role of JNK2-related autophagy on adriamycin-induced drug resistance and the effects of GL-V9 on reversing adriamycin resistance.We concluded that JNK2 played an important role in drug resistance induced by adriamycin.The high expression of JNK2 activated protective autophagy in Hep G2-DOXR cells under non-stress condition,which protected cells from drug attacking.Furthermore,we found that GL-V9 reversed adriamycin resistance by blocking the JNK2-related protective autophagy in HCC.

关 键 词：GL-V9 Drug resistance JNK2 AUTOPHAGY 

分 类 号：R965[医药卫生—药理学]