三阴性乳腺癌术后骨转移与血清PRL、IL-1β以及BSP表达之间的关联探索  

A study of the association between bone metastasis and serum PRL,IL-1β and BSP expression in triple negative breast cancer patients

作　　者：马宇光[1] 赵芳[1] 王梦 梁亮[1] 贾丽君[1] 张淑群[1] MA Yuguang;ZHAO Fang;WANG Meng;LIANG Liang;JIA Lijun;ZHANG Shuqun(Department of Oncology,the Second Affiliated Hospital of Medical College,Xi’an Jiaotong University,Xi'an 710004,Shaanxi,China)

机构地区：[1]西安交通大学第二附属医院肿瘤科,陕西西安710004

出　　处：《中南医学科学杂志》2020年第4期403-405,共3页Medical Science Journal of Central South China

摘　　要：为了分析三阴性乳腺癌切除术后骨转移与血清泌乳素(PRL)、白细胞介素(IL)-1β及骨唾液酸蛋白(BSP)关系,回顾分析三阴性乳腺癌患者的病例。结果显示,术后,发生骨转移患者的血清PRL、IL-1β及BSP水平均显著升高,血清PRL、IL-1β及BSP水平在不同年龄骨转移患者中存在显著差异,且PRL与IL-1β,IL-1β与BSP,PRL与BSP水平间均呈正相关。结果说明,三阴性乳腺癌切除后发生骨转移与年龄因素有关,血清PRL、IL-1β及BSP与三阴性乳腺癌切除后骨转移呈正相关。To analyze the relationship between bone metastasis and PRL,IL-1βand BSP after three negative breast cancer resection,the clinical data of patients with triple negative breast cancer were retrospective anlyzed.The results showed,there were significant differences in serum PRL,IL-1βand BSP levels than before operation,compared to non-bone metastasis group,the bone metastasis group had a significant correlation between the levels of serum PRL,IL-1β,BSP and the age of patients,and PRL levels were positively correlated with IL-1βlevels,and IL-1βlevels were positively correlated with BSP levels,and the level of PRL was positively correlated with BSP level.The results indicated the levels of serum PRL,IL-1βand BSP in patients with bone metastasis after triple-negative breast cancer was correlated to age,and there was a good correlation between serum PRL,IL-1β,BSP levels and bone metastasis after triple-negative breast cancer resection.

关 键 词：三阴性乳腺癌 切除 骨转移 血清泌乳素 白细胞介素-1β 骨唾液酸蛋白 

分 类 号：R737.9[医药卫生—肿瘤]