帕金森病不同运动障碍亚型的临床特征比较  

Comparison of clinical characteristics of Parkinson's disease with different dyskinesia subtypes

作　　者：庞坚信[1] 黄沛钰[2] 王冬女[1] 黄善强[1] 刘素芝[1] PANG Jianxin;HUANG Peiyu;WANG Dongnv;HUANG Shanqiang;LIU Suzhi(Taizhou Hospital of Zhejiang Province,Linhai317000,China;The Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou310009,China)

机构地区：[1]浙江省台州医院,浙江临海317000 [2]浙江大学医学院附属第二医院,浙江杭州310009

出　　处：《中国现代医生》2020年第16期17-20,24,共5页China Modern Doctor

基　　金：浙江省基础公益研究计划项目(LGF20H090009)。

摘　　要：目的比较不同运动障碍亚型帕金森病患者的临床特征,提高对帕金森病运动障碍的认识。方法收集帕金森病患者76例,据统一帕金森病评估量表(UPDRS)评分分为震颤为主型PD(TD-PD)组19例、姿势异常步态障碍为主型PD(PIGD-PD)组47例和不确定型PD组10例,记录所有PD患者年龄、性别、受教育程度、病程、起病年龄、起病部位、UPDRS评分、改良Hoehn-Yahr分期评分、简易精神状态监测量表(MMSE)评分、蒙特利尔认知量表(MoCA)评分、老年抑郁量表(GDS-15)评分、汉密尔顿焦虑量表(HAMA)评分、汉密尔顿抑郁量表(HAMD)评分、生活质量量表(PDQ-8)评分、Berg平衡量表(BBS)评分、冻结步态量表(NFOG-Q)评分、便秘临床评分量表(CCS)评分和便秘生活质量量表(PAC-QOL)评分,统计分析TD-PD组和PIGD-PD组临床特征的差异。结果性别构成在两组之间存在显著性差异(P<0.05),TD-PD组男性较多,而PIGD-PD组女性较多。两组患者UPDRS-Ⅰ、UPDRS-Ⅱ、改良Hoehn-Yahr分期、GDS-15、HAMA、HAMD、BBS、NFOG-Q、PAC-QOL评分均存在显著性差异(P<0.05)。结论帕金森病不同运动障碍亚型之间存在明显的异质性,提高对运动障碍亚型的认识利于分组诊治。Objective To compare the clinical characteristics of patients with different dyskinesia subtypes of Parkinson's disease and improve their understanding of Parkinson's disease with dyskinesia.Methods A total of 76 patients with Parkinson's disease were collected and divided into tremor dominant PD(TD-PD)group(n=19),posture instability and gait disorder(PIGD-PD)group(n=47)and uncertain PD group(n=10),according to the unified Parkinson's disease rate scale(UPDRS)score.All PD patients'age,gender,education level,course of disease,age of onset,location of onset,UPDRS score,modified Hoehn-Yahr stage score,mini-mental state examination(MMSE)score,Montreal cognitive assessment(MoCA)score,Geriatric depression scale(GDS-15)score,Hamilton anxiety scale(HAMA)score,Hamilton depression scale(HAMD)score,Parkinson's disease quality of life scale(PDQ-8)score,Berg balance scale(BBS)score,frozen gait scale(NFOG-Q)score,constipation clinical score scale(CCS)score,and constipation quality of life scale(PAC-QOL)score were recorded.The differences in clinical characteristics between the TD-PD group and the PIGD-PD group were statistically analyzed.Results There was a significant difference in gender composition between the two groups(P<0.05).There were more males in the TD-PD group and more females in the PIGD-PD group.There were significant differences in UPDRS-Ⅰ,UPDRS-Ⅱ,modified Hoehn-Yahr staging,GDS-15,HAMA,HAMD,BBS,NFOG-Q,and PAC-QOL scores between the two groups(P<0.05).Conclusion There are obvious heterogeneity among different dyskinesia subtypes in Parkinson's disease.Improving the understanding of dyskinesia subtypes is helpful for group diagnosis and treatment.

关 键 词：帕金森病 震颤 姿势异常步态障碍 运动障碍亚型 临床特征 

分 类 号：R742.5[医药卫生—神经病学与精神病学]