血清PTX-3、CTRP9、MIF水平与缺血性脑卒中患者神经功能及短期预后的关系  

Relationship between serum PTX-3,CTRP9,MIF levels and neurological function and short-term prognosis in patients with ischemic stroke

作　　者：袁大华[1] 杜朴[1] 王玉凯[1] YUAN Dahua;DU Pu;WANG Yukai(Department of Neurology,Foshan First People's Hospital,Foshan,Guangdong,China,528000)

机构地区：[1]佛山市第一人民医院神经内科,广东佛山528000

出　　处：《分子诊断与治疗杂志》2020年第7期935-939,共5页Journal of Molecular Diagnostics and Therapy

基　　金：佛山市卫生局课题(20190031)。

摘　　要：目的探讨血清正五聚蛋白3(PTX-3)、补体Clq肿瘤坏死因子相关蛋白9(CTRP9)、巨噬细胞迁移抑制因子(MIF)水平与缺血性脑卒中患者神经功能及短期预后的关系.方法选取本院2017年7月至2018年7月收治的缺血性脑卒中患者180例作为研究对象,根据神经功能缺损情况分为重度(n=56)、中度(n=76)、轻度(n=48).比较不同神经功能缺损程度及不同预后患者血清PTX-3、CTRP9、MIF水平、美国国立卫生研究院卒中量表(NIHSS)评分,分析血清PTX-3、CTRP9、MIF与NI-HSS、生活能力评分(mRs)评分的相关性,受试者工作特征(ROC)曲线及ROC曲线下面积(AUC)分析各血清指标对短期预后的预测价值.结果血清PTX-3、MIF与NIHSS、mRs评分呈正相关,CTRP9水平与NIHSS、mRs评分呈负相关(P<0.05);预测短期预后的AUC:治疗5 d PTX-3>治疗5 d MIF>治疗5 d CTRP9>治疗3 d MIF>治疗3 d CTRP9>治疗3 d PTX-3,差异有统计学意义(P<0.05);治疗5 d血清PTX-3、CTRP9、MIF联合预测短期预后的AUC为0.915,大于治疗3 d的0.887(P<0.05).结论血清PTX-3、MIF与缺血性脑卒中患者神经功能、短期预后呈正相关,CTRP9水平与神经功能、短期预后呈负相关,三者联合能可靠预测患者短期预后.Objective To investigate the relationship between serum polypentamin 3(PTX-3),complement Clq tumor necrosis factor-related protein 9(CTRP9),macrophage migration inhibitory factor(MIF)levels and neurological function and short-term prognosis in patients with ischemic stroke.Methods180 patients with ischemic stroke admitted to our hospital from July 2017 to July 2018 were selected as the research objects,according to the neurological deficit,they were divided into severe(n=56),moderate(n=76),mild(n=48).Compared serum PTX-3,CTRP9,MIF levels and National Institutes of Health Stroke Scale(NIHSS)scores for patients with different degrees of neurological deficits and different prognosis,Pearson analysis of the correlation between serum PTX-3,CTRP9,MIF and NIHSS,viability score(mRs)scores,the receiver operating characteristic(ROC)curve and the area under the ROC(AUC)were performed to analyze the predictive value of each serum index for short-term prognosis.Results Serum PTX-3 and MIF levels were positively correlated with NIHSS and mRs scores,and CTRP9 level was negatively correlated with NIHSS and mRs scores(P<0.05).The AUC to predict short-term prognosis:PTX-3 level after 5 days of the treatment>MIF>CTRP9 t>MIF after 3 days of the treatment>CTRP9>PTX-3(P<0.05).The AUC of serum PTX-3,CTRP9,and MIF combined to predict short-term prognosis for five days of the treatment was 0.915,greater than that of three days of treatment(0.887,P<0.05).Conclusion Serum PTX-3 and MIF levels are positively correlated with neurological function and short-term prognosis in patients with ischemic stroke,CTRP9 level is negatively correlated with neurological function and short-term prognosis.The combination of the three can reliably predict the short-term prognosis of patients.

关 键 词：PTX-3 CTRP9 MIF 缺血性脑卒中 神经功能 短期预后 

分 类 号：R743.3[医药卫生—神经病学与精神病学]