根除幽门螺杆菌对冠心病患者长期服用小剂量阿司匹林所致消化道损害的影响  

Impact of Helicobacter pylori eradication therapy and low dose Aspirin on upper digestive tract mucosal injury among patients with coronary heart disease

作　　者：李群山[1] 宋斌[2] 梁桂玲[2] LI Qun-shan;SONG Bin;LIANG Gui-ling(Department of Laboratory Medicine,Huizhou Traditional Chinese Medicine Hospital,Guangdong Province,Huizhou 516001,China;Endoscopy Center,Huizhou Traditional Chinese Medicine Hospital,Guangdong Province,Huizhou516001,China)

机构地区：[1]广东省惠州市中医医院检验科,广东惠州516001 [2]广东省惠州市中医医院内镜中心,广东惠州516001

出　　处：《中国当代医药》2020年第20期40-42,共3页China Modern Medicine

基　　金：广东省惠州市科技计划项目(2015Y101)。

摘　　要：目的探讨根除幽门螺杆菌(Hp)对冠心病患者长期小剂量服用阿司匹林致上消化道黏膜损伤的影响,为临床决策提供依据。方法选取2014年1月~2015年12月我院诊治的105例冠心病合并Hp感染患者为研究对象,采用随机数字表法将其分为Hp根除组(n=52)和对照组(n=53)。Hp根除组按标准方案治疗Hp,对照组常规治疗,随访6个月,比较两组的消化道症状和上消化道黏膜损伤发生率。结果随访6个月后,Hp根除组和对照组消化道症状(疼痛、反酸、黑便、大便潜血阳性)发生率分别为19.2%和49.1%;上消化道黏膜伤发生率分别为7.7%和22.6%;Hp根除组消化道症状和上消化道黏膜损伤总发生率低于对照组,差异有统计学意义(P<0.05)。结论根除Hp可降低长期小剂量服用阿司匹林冠心病患者上消化道黏膜损伤风险。Objective To investigate the impact of Helicobacter pylori eradication therapy(Hp)and low dose Aspirin on upper digestive tract mucosal injury among patients with coronary heart disease,and to provide evidence for making clinical decision.Methods A total of 105 patients combined with coronary heart disease and Hp infection were selected from January 2014 to December 2015 in our hospital.The patients were divided into Hp group(n=52)and control group(n=53)by using random number table method.Hp group received anti-Hp treatment according to standard protocol,and control group received routine treatment.The patients were followed up for 6 months,the occurrence of gastrointestinal symptoms and upper gastrointestinal mucosal injury were observe between two groups.Results The occurrence of gastrointestinal symptoms in Hp group and control group was 19.2%and 49.1%respectively;the occurrence of upper gastrointestinal mucosal injury in Hp group and control group was 7.7%and 22.6%respectively.The total occurrence rates of gastrointestinal symptoms and upper gastrointestinal mucosal injury were lower in Hp group than those in the control group,the differences were statistically significant(P<0.05).Conclusion To reduce the risk of gastrointestinal symptoms and upper gastrointestinal mucosal injury,patients combined with coronary atherosclerosis and Hp infectious should eradicate Hp infections.

关 键 词：冠心病 阿司匹林 幽门螺杆菌 

分 类 号：R573.1[医药卫生—消化系统]