血清Gal-3水平与脓毒症患者病情危重程度及预后关系的研究  

Relationship between serum Gal-3 level and disease severity and prognosis in pyemia patients

作　　者：曾永红[1] ZENG Yonghong(Department of Emergency,the First People's Hospital of Zigong,Zigong,Sichuan,643000,China)

机构地区：[1]自贡市第一人民医院急诊科,四川自贡643000

出　　处：《临床急诊杂志》2020年第5期384-388,共5页Journal of Clinical Emergency

摘　　要：目的:探究血清半乳糖凝集素-3(Gal-3)水平与脓毒症患者病情危重程度及预后的关系。方法:选择2014-02—2018-12期间收治的85例脓毒症患者和72例全身炎症反应综合征非脓毒症患者,分别作为脓毒症组和对照组,采用ELISA法检测两组患者血清Gal-3水平,分析两组患者血清中Gal-3水平。结果:脓毒症组患者体温、白细胞计数、APACHEⅡ评分、病死率、血清CRP及Gal-3水平均显著高于对照组(均P<0.05);脓毒性休克患者体温、白细胞计数、APACHEⅡ评分、病死率及血清Gal-3水平均显著高于未休克患者(均P<0.05);死亡脓毒症患者体温、白细胞计数、APACHEⅡ评分、血清CRP及Gal-3水平均显著高于存活患者(均P<0.05);Gal-3水平是脓毒症患者病情危急程度及预后的独立风险因素;Gal-3水平预测脓毒症病情的曲线下面积(AUC)为0.729,敏感度为71.80%,特异度为64.3%,95%CI为0.571~0.888;Gal-3水平预测脓毒症预后情况的AUC为0.692,敏感度为87.80%,特异度为50.00%,95%CI为0.574~0.810;脓毒症患者血清Gal-3水平与APACHEⅡ评分呈正相关(r=0.726,P=0.016)。结论:Gal-3水平在脓毒症患者中显著升高,对其病情严重程度和预后情况有一定的预测价值。Objective:To investigate the relationship between serum galectin-3(Gal-3)level and disease severity,prognosis in pyemia patients.Method:Eighty-five pyemia patients and 72 patients with systemic inflammatory response syndrome and non-pyemia admitted from February 2014 and December 2018 were enrolled.The two kinds of patients were divided into pyemia group and control group,respectively.Serum Gal-3 levels in both groups were measured by ELISA method.The Gal-3 levels in serum of the two groups were analyzed.Result:Body temperature,white blood cell count,score of acute physiology and chronic health evaluation systemⅡ(APACHEⅡ),mortality,serum CRP and Gal-3 levels in pyemia group were significantly higher than those in control group(P<0.05).Body temperature,white blood cell count,APACHEⅡscore,mortality and serum Gal-3 level in pyemia patients with shock were significantly higher than those without shock(P<0.05).Body temperature,white blood cell count,APACHEⅡscore,serum CRP and Gal-3 levels in dead pyemia patients were significantly higher than those in survival patients(P<0.05).Gal-3 level was an independent risk factor for severity and prognosis of pyemia patients.The area under the curve(AUC),sensitivity,specificity and 95%CI of Gal-3 level for predicting pyemia severity were 0.729,71.80%,64.3%and 0.571-0.888,respectively.The above 4 indexes of Gal-3 level for predicting prognosis were 0.692,87.80%,50.00%and 0.574-0.810,respectively.The serum Gal-3 level was positively correlated with APACHEⅡscore in pyemia patients(r=0.726,P=0.016).Conclusion:Gal-3 level is significantly increased in pyemia patients,which is of certain predictive value for disease severity and prognosis.

关 键 词：血清半乳糖凝集素-3 脓毒症 病情危重程度 预后 

分 类 号：R737.9[医药卫生—肿瘤]