中性粒细胞胞外诱捕网及其参与的免疫炎症性疾病研究进展  

Research progress on neutrophil extracellular traps and related immune-inflammatory diseases

作　　者：刘春晓 胡庆华[1] LIU Chunxiao;HU Qinghua(School of Pharmacy,China Pharmaceutical University,Nanjing 211198,China)

机构地区：[1]中国药科大学药学院,江苏南京211198

出　　处：《药学研究》2020年第7期405-410,共6页Journal of Pharmaceutical Research

基　　金：国家自然科学基金(No.81773745)。

摘　　要：中性粒细胞是人固有免疫系统中含量最丰富的一类免疫效应细胞,主要通过吞噬作用、氧化应激以及形成中性粒细胞胞外诱捕网(neutrophil extracellular traps,NETs)发挥其免疫活性。然而过量的中性粒细胞胞外诱捕网也可能会造成组织损伤,参与疾病的病理过程,尤其是在炎症性疾病或自身免疫性疾病中。本文主要围绕中性粒细胞胞外诱捕网的形成、调节过程、中性粒细胞胞外诱捕网参与免疫炎症性疾病的病理过程展开综述,同时对现有的干扰中性粒细胞胞外诱捕网形成的小分子化合物和可能通过调节中性粒细胞胞外诱捕网产生起到治疗疾病作用的药物进行总结。Neutrophils are the most abundant type of immune effector cells in the human innate immune system.They exert their immune functions mainly through phagocytosis,oxidative stress,and the formation of neutrophil extracellular traps(NETs).However,excessive NETs may also cause tissue damage and participate in the pathological process of the disease,especially in inflammatory diseases or autoimmune diseases.This article mainly focused on the formation and regulation of NETs,the pathological process of NETs involved in immune inflammatory diseases,and summarized the existing small molecule compounds that interfere with the formation of NETs and the drugs that may play a role in treating diseases by regulating the production of NETs.

关 键 词：中性粒细胞胞外诱捕网(NETs) 弹性蛋白酶 肽酰基精氨酸脱亚氨酶 炎症性疾病 自身免疫病 研究进展 

分 类 号：R364.5[医药卫生—病理学]