血清SHBG表达及对维吾尔族妊娠期糖尿病诊断价值  

Serum SHBG expression and diagnostic value for Uygur gestational diabetes mellitus

作　　者：沈娟娟[1] 蔡珏瑾[1] 哈丽亚[1] SHEN Juanjuan;CAI Juejin;HA Liya(Department of Obstetrics and Gynecology,the Second Affiliated Hospital of Xinjiang Medical University,Xinjiang Uygur Autonomous Region,Urumqi830063,China)

机构地区：[1]新疆医科大学第二附属医院妇产科,新疆乌鲁木齐830063

出　　处：《中国医药导报》2020年第20期111-114,共4页China Medical Herald

基　　金：新疆维吾尔自治区自然科学基金资助项目(2018D01C233)。

摘　　要：目的探讨新疆地区维吾尔族妊娠期糖尿病(GDM)妇女不同妊娠阶段血清性激素结合球蛋白(SHBG)表达,及对维吾尔族GDM诊断价值。方法选择2018年8月~2019年8月新疆医科大学第二附属医院维吾尔族GDM患者100例为观察组,同期健康体检维吾尔族孕妇100名为对照组。比较两组孕早、中期和晚期血清SHBG、空腹血糖、空腹胰岛素、糖化血红蛋白(HbA1c)和空腹C肽水平,计算HOMA-IR值,分析孕早期SHBG水平与其他指标的相关性;受试者工作曲线(ROC)分析孕早期SHBG水平对GDM的诊断价值。结果观察组孕早、中期和晚期血清SHBG水平明显低于对照组,差异均有统计学意义(均P<0.05);观察组孕中、晚期HbA1c、空腹C肽水平、空腹血糖、空腹胰岛素及HOMA-IR值高于对照组,差异均有统计学意义(均P<0.05)。孕早期血清SHBG水平与HOMA-IR值呈显著负相关(r=-0.869,P<0.01)。孕早期SHBG水平诊断GDM的曲线下面积为0.877。结论在不同妊娠阶段,新疆地区维吾尔族GDM孕妇血清SHBG水平均较低,且与IR程度呈负相关,孕早期血清SHBG水平可作为早期诊断GDM的重要生化指标。Objective To investigate serum sex hormone binding globulin(SHBG)expression in gestational diabetes mellitus(GDM)of Uygur women in Xinjiang and its diagnostic value for GDM.Methods From August 2018 to August2019,100 cases with Uygur GDM patients in the Second Affiliated Hospital of Xinjiang Medical University were selected as the observation group,100 Uygur pregnant women in the same period of health examination as the control group.The serum SHBG,fasting blood glucose,fasting insulin,glycosylated hemoglobin(HbA1 c)and fasting C peptide level were compared between the two groups of pregnant women in early,middle and late pregnancy.The HOMA-IR was calculated,and the correlation between SHBG level in early pregnancy and other indicators were recorded.The receiver operating characteristic(ROC)was used to analyze the diagnostic value of SHBG level in early pregnancy for GDM.Results The serum SHBG levels in the observation group were lower than those in the control group in early middle and late pregnancy,and the differences were statistically significant(P<0.05).HbA1 c,fasting C peptide level,fasting blood glucose,fasting insulin and HOMA-IR in the observation group were higher than those in the control group in early middle and late pregnancy,and the differences were statistically significant(all P<0.05).Serum SHBG level of early pregnancy was negatively correlated with HOMA-IR values(r=-0.869,P<0.01).The area under the curve of SHBG level in the early pregnancy for diagnosis of GDM was 0.877.Conclusion In different pregnancy stages,serum SHBG level of Uygur GDM pregnant women in Xinjiang is lower and negatively correlated with IR degree.Serum SHBG level in early pregnancy can be an important biochemical indicator for early diagnosis of GDM.

关 键 词：维吾尔族 妊娠期糖尿病 性激素结合球蛋白 胰岛素抵抗 

分 类 号：R741.256[医药卫生—神经病学与精神病学]