CYP2D6基因多态性对托烷司琼预防化疗所致恶心呕吐效果的影响  

Influence of CYP2D6 gene polymorphism on the effect of tropisetron in preventing chemotherapy induced nausea and vomiting

作　　者：唐慕菲[1] 沈芸竹 张保国[2] TANG Mufei;SHEN Yunzhu;ZHANG Baoguo(Department of Pharmacy,Nanjing First Hospital,Nanjing Medical University,Nanjing 210006,China;Department of Oncology,Nanjing First Hospital,Nanjing Medical University,Nanjing 210006,China)

机构地区：[1]南京医科大学附属南京医院(南京市第一医院)药学部,江苏南京210006 [2]南京医科大学附属南京医院(南京市第一医院)肿瘤内科,江苏南京210006

出　　处：《中国临床药理学与治疗学》2020年第7期817-822,共6页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：江苏省博士后日常资助项目(2018Z092);南京市药学会-常州四药医院药学科研基金项目(2018YX007)。

摘　　要：肿瘤对人类健康造成很大威胁。化疗作为一种全身性的治疗方法,在肿瘤治疗中的地位不可动摇。化疗所致恶心呕吐(chemotherapy induced nausea and vomiting,CINV)是化疗过程中常见的不良反应,严重影响了患者的情绪、生活质量和肿瘤的控制。CINV的防治对肿瘤患者来说非常重要。托烷司琼是较常用的5-羟色胺Ⅲ亚型(5-hydroxytryptamine type 3,5-HT3)受体拮抗剂,在防治CINV方面具有很好的临床效果,但仍有部分患者使用托烷司琼后效果不佳。越来越多的研究表明这些个体差异可能与基因多态性密切相关。本文就细胞色素P4502D6(cytochrome P4502D6,CYP2D6)基因多态性对托烷司琼预防CINV效果的影响作一综述,以期为基因多态性指导下的临床个体化用药提供思路。Tumors pose a great threat to human health.As a systemic treatment,chemotherapy has held an unshakable position in tumor treatment.Chemotherapy induced nausea and vomiting(CINV)is a common adverse reaction during chemotherapy,which seriously affects patients’mood,quality of life and tumor control.The prevention and treatment of CINV is very important for cancer patients.As a more commonly used 5-HT3 receptor antagonist,tropisetron has a good clinical effect in the prevention and treatment of CINV.However,there are still some patients who do not have a good effect after using tropisetron.More and more studies indicated that these individual differences might be closely related to genetic polymorphisms.In order to provide ideas for clinical individualized medication under the guidance of gene polymorphisms,this article reviewed the influence of CYP2 D6 gene polymorphisms on the effect of tropisetron in preventing CINV.

关 键 词：托烷司琼 化疗所致恶心呕吐 CYP2D6 基因多态性 

分 类 号：R730.5[医药卫生—肿瘤] R969[医药卫生—临床医学]