化浊解毒通络法对血管性痴呆脑血管功能、Livin、TGF-β的影响  

Effect of Resolving Turbid,Relieving Toxin and Dredging Collateral Method on Cerebrovascular Function,Livin and TGF-β of Patients with Vascular Dementia

作　　者：陈芳[1] 杜蓉[1] 杨玲[1] CHEN Fang;DU Rong;YANG Ling(Department of Neurology,Panzhihua Central Hospital,Panzhihua 617000,Sichuan,China)

机构地区：[1]攀枝花市中心医院神经内科,四川攀枝花617000

出　　处：《中华中医药学刊》2020年第6期55-57,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：国家中医药管理局国家中医临床研究基地业务建设专项(JDZX2016879)。

摘　　要：目的分析化浊解毒通络法对血管性痴呆患者脑血管功能、抗凋亡因子(Livin)、转化生长因子-β(TGF-β)影响情况。方法选取医院2017年2月—2019年2月收治的血管性痴呆患者94例,分为两组。对照组给予常规对症治疗,观察组加用化浊解毒通络法,分析两组患者治疗后的临床疗效。结果两组治疗前Livin、TGF-β、脑源性神经营养因子(BDNF)水平及颅内动脉血流动力学指标组间比较,差异不具有统计学意义(P>0.05)。观察组治疗后颅内动脉收缩期血流速度(Vs)、平均血流速度(Vm)及Livin、TGF-β、BDNF水平高于对照组,颅内动脉搏动指数(PI)水平低于对照组(P<0.05)。两组治疗前简易精神状态评定表(MMSE)评分、日常生活功能量表(ADL)评分组间比较,差异不具有统计学意义(P>0.05)。观察组治疗后MMSE评分(20.10±3.65)分、ADL评分(68.52±6.12)分高于对照组(P<0.05)。观察组不良反应率(8.51%)与对照组(10.64%)比较,差异不具有统计学意义(P>0.05)。结论化浊解毒通络法可改善血管性痴呆患者脑血管功能和认知功能,恢复其日常生活能力,提高Livin、TGF-β、BDNF的表达水平,且安全性高。Objective The effects of resolving turbid,relieving toxin and dredging collateral method on cerebrovascular function,anti-apoptosis factor(Livin)and transforming growth factor-β(TGF-β)of patients with vascular dementia were analyzed.Methods From February 2017 to February 2019,94 patients with vascular dementia were divided into two groups.The control group was treated with routine symptomatic treatment,and the observation group was treated with the method of resolving turbid,relieving toxin and dredging collateral,and the clinical efficacy of the two groups after treatment was analyzed.Results There was no significant difference in the levels of Livin,TGF-β,brain-derived neurotrophic factor(BDNF)or intracranial artery hemodynamics between the two groups before treatment(P>0.05).After treatment,the mean blood flow velocity(Vm),Livin,TGF-βand BDNF of intracranial artery systolic velocity in the observation group were higher than those in the control group,and the PI level of intracranial artery pulsatile index was lower than that in the control group(P<0.05).There was no significant difference between the two groups in MMSE score of simple mental state rating table and ADL score of function of daily living scale before treatment(P>0.05).After treatment,the MMSE score and ADL score in the observation group were(20.10±3.65)points and(68.52±6.12)points,respectively,which were higher than those in the control group(P<0.05).There was no significant difference in the adverse reaction rate between the observation group(8.51%)and the control group(10.64%)(P>0.05).Conclusion The method can improve the cerebrovascular function and the cognitive function of the vascular dementia patients,restore the daily life capacity,improve the expression levels of Livin,TGF-1 and BDNF,and has high safety.

关 键 词：化浊解毒通络法 血管性痴呆 脑血管功能 抗凋亡因子 认知功能 

分 类 号：R749.13[医药卫生—神经病学与精神病学]