药物治疗失败的卡梅现象的临床特点及手术效果  

Clinical features and surgical results of Kasabach-Merritt phenomenon with failed drug therapy

作　　者：王彦林[1] 董长宪[1] 郭晓楠[1] 刘大看[1] 肖莉[1] 左松[1] 任腾飞[1] Wang Yanlin;Dong Changxian;Guo Xiaonan;Liu Dakan;Xiao Li;Zuo Song;Ren Tengfei(Department of Hemangioma Surgery,Henan Provincial People’s Hospital,Zhengzhou 450000,China)

机构地区：[1]河南省人民医院血管瘤外科,郑州450000

出　　处：《中国实用医刊》2020年第8期1-4,共4页Chinese Journal of Practical Medicine

基　　金：2019国家自然科学基金青年科学基金项目(81800991)。

摘　　要：目的探讨药物治疗失败的卡梅现象(KMP)的临床特点及手术效果。方法抽取2012年1月至2017年12月于河南省人民医院经药物治疗失败的KMP患儿47例,男26例,女21例,年龄1~11个月,行单纯血管瘤切除术或血管瘤切除+原位植皮术。分析其临床表现、术中及术后情况。结果47例患儿年龄较小,血管瘤发展至KMP时间为0~11个月,瘤体位置深且面积大。41例行单纯血管瘤切除术,行血管瘤切除+原位植皮术6例。手术时间35~260 min,出血量20~380 ml,血小板计数术后1~9 d恢复正常、2~60 d出现峰值,住院时间14~72 d,随访24~78个月未见复发、功能障碍者。结论KMP进展时间短,药物保守治疗失败者手术可获得较好的治疗效果。Objective To investigate features and surgical results of Kasabach-Merritt phenomenon(KMP)with failed drug therapy.Methods Forty-seven children with KMP who failed drug treatment in Henan Provincial People’s Hospital from January 2012 to December 2017,26 males and 21 females,aged 1 to 11 months,underwent simple hemangiomas or hemangiomas resection+skin graft in situ.The clinical manifestations,intraoperative and postoperative conditions of them were analyzed.Results Forty-seven children were younger.The time from hemangioma to KMP was 0 to 11 months.The tumor was deep and large.Forty-one patients underwent simple hemangiomas resection and 6 patients underwent hemangioma resection and skin graft.The operation time was 35 to 260 minutes,and the bleeding volume was 20 to 380 ml.The platelet count returned to normal on the 1 to 9 days after surgery,the peak appeared at 2 to 60 days,and the hospitalization time was 14 to 72 days.No recurrence or dysfunction patients was found after follow-up for 24 to 78 months.Conclusions The progression time of KMP is short,and the patients who fail in conservative treatment of medicine can get better treatment effect.

关 键 词：卡梅现象 血管瘤 植皮 

分 类 号：R73[医药卫生—肿瘤]