女性化疗患者卵巢功能保护的研究进展  

Advances in the protection of ovarian function in female patients during chemotherapy

作　　者：楚培源 吴衡慧 Chu Peiyuan;Wu Henghui(Department of Obstetrics and Gynecology,Henan University People’s Hospital,Henan Provincial People’s Hospital,Zhengzhou 450003,China)

机构地区：[1]河南大学人民医院河南省人民医院妇产科,郑州450003

出　　处：《中国实用医刊》2020年第8期118-122,共5页Chinese Journal of Practical Medicine

摘　　要：化疗作为恶性肿瘤的有效治疗手段,能改善患者预后,延长生存期,甚至达到临床治愈的效果。化疗能杀灭肿瘤细胞,也会损害育龄期女性患者卵巢功能。卵母细胞冻存、胚胎冻存、卵巢组织冻存、促性腺激素释放激素激动剂、促性腺激素释放激素拮抗剂为临床常用的保护卵巢功能的措施,部分药物对卵巢影响的确切机制尚不明确,其疗效尚存争议。As an effective treatment for malignant tumors,chemotherapy can significantly improve the prognosis of patients,prolong the survival period and even achieve the effect of clinical cure.Chemotherapy can kill tumor cells,and may damage the ovarian function of female patients of reproductive age.Cryopreservation of oocytes,embryos,and ovarian tissues,gonadotropin releasing hormone agonist,and gonadotropin releasing hormone antagonist are commonly used measures to protect ovarian function.The exact mechanism of the effects of some drugs on the ovaries is not clear,and the efficacy is still controversial.

关 键 词：卵巢 生育功能 冻存技术 促性腺激素释放激素类似物 

分 类 号：R737[医药卫生—肿瘤]