长链非编码RNA与肝细胞癌的研究进展  

Application of long non-coding RNA in hepatocellular carcinoma

作　　者：王慧[1] 张学龙[2] 王玺[1] Wang Hui;Zhang Xuelong;Wang Xi(Department of Gastroenterology,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第一医院消化内科,150001 [2]哈尔滨医科大学医学遗传学研究室,150081

出　　处：《国际免疫学杂志》2020年第2期190-195,共6页International Journal of Immunology

基　　金：国家自然科学基金青年基金(81302062)。

摘　　要：肝细胞癌(hepatocellular carcinoma,HCC)是一种复杂性疾病,大部分确诊时为晚期,因此早期诊断、治疗尤为重要。近年来研究发现,部分长链非编码RNA(long non-coding RNA,lncRNA)在HCC中具有差异性表达,可作为诊断及评估预后的潜在的生物标志物。研究者陆续发现单核苷酸多态性(single nucleotide polymorphism,SNP)可影响lncRNA的表达,与HCC的发生发展密切相关。lncRNA及其SNPs在HCC诊断、治疗和预后方面发挥的重要作用,可为未来进一步研究及应用提供帮助。Hepatocellular Carcinoma(HCC)is a complex disease,most of which are advanced when diagnosed,so early diagnosis and treatment are particularly important.In recent years,several long non-coding RNA(lncRNA)have been found differential expression in HCC.lncRNA can be used as a potential biomarker for the diagnosis and prognosis of HCC.Researchers have found that single nucleotide polymorphism(SNP)can affect the expression of lncRNA,which is closely related to the occurrence and development of HCC.Recent advance in the application of lncRNA in the diagnosis,treatment and prognosis of HCC to provide reference for further research and application were summarized in this review.

关 键 词：长链非编码RNA 基因多态性 肝细胞癌 

分 类 号：R735[医药卫生—肿瘤]