年轻宫颈鳞癌患者手术治疗同时行腹腔镜卵巢移位术对术后卵巢功能及其并发症的影响  

The Effect of Laparoscopic Ovarian Transection on Ovarian Function and Complications in Young Patients with Cervical Squamous Cell Carcinoma

作　　者：江娜 程欣 王秀虹 JIANG Na;CHENG Xin;WANG Xiuhong(Xianning Center Hospital,Xianning,437100)

机构地区：[1]湖北省咸宁市中心医院,437100

出　　处：《实用癌症杂志》2020年第7期1196-1199,共4页The Practical Journal of Cancer

基　　金：湖北省自然科学基金(编号:2018CFD828)。

摘　　要：目的探讨年轻宫颈鳞癌患者宫颈癌手术治疗时同时行卵巢位移术对术后卵巢功能及其并发症的影响的影响分析。方法选取89例宫颈癌患者,按照手术方式不同分为对照组和卵巢移位组,两组患者均接受了放疗,治疗后随访,分析其对卵巢功能保留情况、血清性激素水平,比较治疗6个月后患者的Kupperman评分及不良反应。结果卵巢移位组卵巢功显著优于对照组,差异有统计学意义(χ^2=16.717,P<0.001)。两组患者放疗前性激素水平差异无统计学意义(P>0.05)。与放疗前相比较,放疗后两组患者的FSH及LH水平均增高,但是对照组升高更明显,差异均有统计学意义(P均<0.05);放疗后两组患者的E2水平均下降,但是对照组降低更明显,差异均有统计学意义(P均<0.05)。卵巢转位组Kupperman评分<5分的比例和Kupperman评分明显优于对照组,差异均有统计学意义(P<0.05)。随访过程中两组卵巢囊肿、腹痛、肠梗阻、膀胱炎发生率无显著性差异(P>0.05)。结论宫颈癌放疗前进行卵巢移位能够显著改善患者卵巢功能,调节患者性激素水平,提高术后生活质量,但长期生存率和复发率仍有待进一步研究。Objective To investigate the effect of ovarian displacement on ovarian function and its complications in young patients with cervical carcinoma.Methods 89 patients with cervical cancer were divided into the control group and ovarian transposition group according to different surgical methods.The patients in both groups were followed up after treatment.The retention of ovarian function and serum sex hormone levels were analyzed.The kupperman score and adverse reactions were compared after 6 months of treatment.Results The ovarian function of the ovarian transfer group was significantly better than that of the control group,and the difference was statistically significant(χ^2≤16.717,P<0.001).There was no significant difference in sex hormone levels between the 2 groups before radiotherapy(P>0.05).Compared with before radiotherapy,the levels of FSH and LH in the 2 groups increased after radiotherapy,but the levels of E2 in the control group were significantly higher than those before radiotherapy,and the levels of E2 in the 2 groups decreased after radiotherapy,but the decrease was more obvious in the control group,and the difference was statistically significant(P<0.05).The proportion of kupperman score<5 and kupperman score in ovarian transposition group were significantly better than those in control group(P<0.05).There was no significant difference in the incidence of ovarian cysts,abdominal pain,intestinal obstruction and cystitis between the 2 groups(P>0.05).Conclusion Ovarian transposition before radiotherapy can significantly improve ovarian function,regulate sex hormone level and improve postoperative quality of life in patients with cervical cancer,but the long-term survival rate and recurrence rate still need to be further studied.

关 键 词：年轻宫颈鳞癌 手术治疗 卵巢位移术 卵巢功能 并发症 

分 类 号：R737.33[医药卫生—肿瘤]