利培酮合并电休克治疗对分裂症患者血清C反应蛋白影响的对照研究  

Effect of risperidone and electroconvulsive therapy on serum C-reactive protein in schizophrenic patients

作　　者：曹月梅 成红霞[3] 陈宽玉 肖文焕 CAO Yuemei;CHENG Hongxia;CHEN Kuanyu(Wutaishan hospital of Yangzhou,Yangzhou 225003,China)

机构地区：[1]江苏省扬州五台山医院,扬州225000 [2]扬州市精神卫生防治中心 [3]苏北人民医院

出　　处：《国际精神病学杂志》2020年第3期472-474,488,共4页Journal Of International Psychiatry

摘　　要：目的比较利培酮单用或联合改良电抽搐治疗(MECT)对精神分裂症患者血清C反应蛋白(CRP)的影响。方法收集只接受利培酮治疗(服药组)和联合接受改良电休克治疗(MECT组)的患者及正常人(正常组)各30例,观察4周,采用阳性和阴性症状量表(PANSS)对患者治疗前后精神症状进行评定,同时检测患者治疗前后和正常人的血清CRP浓度。结果治疗前两组患者血清CRP浓度均高于正常组(P<0.01);治疗后两组血清CRP浓度均低于治疗前(P<0.01),但是仍然高于正常组(P<0.01)。两组患者中治疗有效者血清CRP浓度显著低于治疗前(P<0.01),治疗无效者治疗前后血清CRP浓度差异均无统计学意义(P>0.05)。结论MECT和抗精神病药物治疗均可能通过降低炎症水平(降低CRP)而起到抗精神病的作用。Objective To explore the effect of modified electroconvulsive therapy(MECT)and risperidone on serum C-reactive protein(CRP)in schizophrenia patients.Method Collect only accept risperidone treatment in schizophrenia(Medication group),and select the age-and sex-matched 30 schizophrenia(MECT group)who were treated with MECT and risperidone.The serum CRP levels were measured by enzyme-linked immunosorbent assay in schizophrenia patients before and after treatment and 30 normal controls(Normal group).A positive and negative syndrome scale(PANSS)questionnaire has been used to recognize the severity of the disease and to assess the response to treatment.Results Before treatment,the serum CRP levels in two patient groups were significantly higher than the levels in normal group(P<0.01).After treatment,the serum CRP levels are significantly decrease as compare to before treatment in patient groups(P<0.01),but still higher than normal group(P<0.01).CRP levels in patient groups of responders after treatment were lower than before treatment(P<0.01).No statistical significance in non-responders(P>0.05).Conclusion MECT and antipsychotic medications may play a role in schizophrenia through decreasing the serum level of CRP.

关 键 词：精神分裂症 改良无抽搐电休克治疗 C反应蛋白 

分 类 号：R749.3[医药卫生—神经病学与精神病学]