血清肿瘤标志物联合血常规指标检测在原发性肝癌诊断中的应用研究  

Application of Serum Tumor Markers combined with Blood Routine Indexes in Diagnosis of Primary Liver Cancer

作　　者：毕婧 BI Jing(Department of Clinical Laboratory,Dandong First Hospital,Dandong 118000,China)

机构地区：[1]丹东市第一医院检验科,辽宁丹东118000

出　　处：《中国医药指南》2020年第20期158-159,共2页Guide of China Medicine

摘　　要：目的探讨原发性肝癌诊断中血清肿瘤标志物与血常规联合检测的诊断效果。方法纳入本院2018年1月至2018年12月收治原发性肝癌患者50例建立观察组,同期纳入慢性乙肝患者50例建立对照组,分别对比两组患者血清肿瘤标志物CA199与AFP、血常规指标WBC与NLR检测情况,分析各指标检测相关性。结果观察组患者血清AFP、CA199、WBC与NLR指标水平相比对照组均明显更高,差异存在统计意义(P<0.05);肿瘤分化的程度低、肿瘤病灶直径≥5 cm、肿瘤转移患者血清CA199与AFP水平相对更高(P<0.05);肿瘤病灶直径≥5 cm患者血清WBC水平相对更高,肿瘤病灶直径≥5 cm、转移患者血清NLR水平相对更高(P<0.05)。结论原发性肝癌患者血清WBC与NLR指标水平上升,临床通过进行血清肿瘤标志物CA199与AFP、血常规指标WBC与NLR检测有助于提高对原发性肝癌患者的临床诊断与鉴别诊断效率。Objective To study the diagnostic effect of serum tumor markers and blood routine in the diagnosis of primary liver cancer.Methods 50 cases of primary liver cancer were established in our hospital from January 2018 to December 2018,and 50 cases of patients with chronic hepatitis B were included in the control group.Results The level of serum CA199 and AFP in patients with metastasis was higher than that in patients with metastasis(P<0.05),and the degree of tumor differentiation was low,the diameter of tumor focus was≥5 cm,and the serum level of VEGF was higher in patients with metastasis(P<0.05).The serum WBC level in patients with tumor focus diameter≥5 cm was higher than that in patients with tumor focus diameter≥5 cm,and the serum NLR level in metastatic patients was higher than that in metastatic patients(P<0.05).Conclusion The levels of serum WBC and NLR were increased in patients with primary liver cancer.The detection of serum tumor markers CA199 and AFP,blood routine indexes WBC and NLR is helpful to improve the clinical significance in patients with primary liver cancer.Efficiency of clinical diagnosis and differential diagno sis.

关 键 词：血清肿瘤标志物 血常规指标 原发性肝癌 临床诊断效果 

分 类 号：R735.7[医药卫生—肿瘤]