抑郁症患者纹状体多巴胺D2受体结合力与功能连接的相关性  

Correlation between cerebral striatal dopamine D2 receptors non-displaceable binding potential and functional connectivity in patients with major depressive disorder

作　　者：孙萌萌 轩昂[1,2] 付畅 尤阳[1,2] 高永举 武新宇[1,2] 徐俊玲 Sun Mengmeng;Xuan Ang;Fu Chang;You Yang;Gao Yongju;Wu Xinyu;Xu Junling(Nuclear Medicine Department,Henan Provincial People's Hospital,Zhengzhou 450003,China;Nuclear Medicine Department,People's Hospital of Zhengzhou University,Zhengzhou 450003,China)

机构地区：[1]河南省人民医院核医学科,郑州450003 [2]郑州大学人民医院核医学科,450003

出　　处：《中华行为医学与脑科学杂志》2020年第7期600-606,共7页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：河南省医学科技攻关计划省部共建项目(201701026)。

摘　　要：目的:应用11C-Raclopride PET/CT及rs-fMRI,探讨静息状态下首发抑郁症患者脑纹状体多巴胺D2受体结合力(non-displaceable binding potential,BPND)改变与功能连接(functional connectivity,FC)改变之间的关系,并分析其与临床症状是否具有相关性。方法:选择38例首发抑郁症患者(抑郁症组)及年龄、性别、受教育年数与其相匹配的健康志愿者40名(对照组)。所有受试者均在入组前进行汉密尔顿抑郁量表(24项版本)评分,入组后均在静息状态下接受脑11C-雷氯必利(11C-Raclopride)PET/CT和rs-fMRI检查。采用MIAKAT软件及DPARSF软件分别分析受试者脑纹状体多巴胺D2受体BPND及纹状体与全脑FC,应用SPSS 20.0软件及Rest 1.8软件进行配对样本t检验、两独立样本t检验探讨抑郁症患者脑纹状体多巴胺D2受体BPND及纹状体与全脑FC改变,并应用Pearson相关分析探讨两种改变之间的相关性及其与汉密尔顿抑郁量表评分的相关性。结果:与对照组相比,抑郁症组左右两侧纹状体(尾状核及壳核)D2受体BPND均减低(左侧尾状核:1.16±0.37,1.48±0.39;右侧尾状核:1.21±0.31,1.62±0.48;左侧壳核:1.73±0.47,2.21±0.66;右侧壳核:1.79±0.46,2.17±0.65;t=-3.66,-4.42,-3.68,-2.91,均P<0.001)。与对照组相比,抑郁症组左侧尾状核与左侧内侧前额叶(4.38±1.31,2.35±0.48)、左侧额中回(3.36±1.11,1.64±0.56)及左侧额上回(3.14±0.78,1.64±0.53)FC均增高(t=9.16,8.74,9.95,均P<0.05);抑郁症组左侧壳核与左侧内侧前额叶FC增高(4.10±1.42,2.42±0.64,t=6.82,P<0.05),左侧壳核与左侧前扣带回FC减低(1.60±0.55,2.68±0.84,t=-6.76,P<0.05);抑郁症组右侧尾状核与右侧内侧前额叶FC增高(4.32±1.30,2.33±0.63,t=8.51,P<0.05),右侧尾状核与右侧杏仁核FC减低(1.67±0.57,3.46±0.64,t=-8.27,P<0.05);抑郁症组右侧壳核与右侧内侧前额叶FC增高(3.77±1.25,2.31±0.63,t=6.49,P<0.05)。抑郁症组左侧尾状核BPND同左侧尾状核与左侧内侧前额叶FC值间为负相关Objective:To study the correlation between changes of cerebral striatal dopamine D 2 receptors non-displaceable binding potential(BPND),functional connectivity(FC)and clinical symptoms in patients with first-episode major depressive disorder(MDD),by 11C-Raclopride PET/CT and resting state fMRI(rs-fMRI).Methods:Thirty-eight first-episode depression patients(MDD group)and forty healthy volunteers(control group)matched with age,gender and years of education were selected.All subjects were scored with Hamilton depression scale(24 versions)before enrollment.All the subjects underwent cerebral 11C-Raclopride PET/CT and rs-fMRI in resting state.MIAKAT and DPARSF were used to analyze BPND of cerebral striatal dopamine D2 receptors and FC of striatum and the whole brain in subjects,respectively.Changes of striatal dopamine D2 receptors BPND and striatum and the whole brain FC of MDD were analyzed,and correlations among BPND,FC and Hamilton depression rating scale were calculated by Rest 1.8 and SPSS 20.0.Results:Compared with the control group,BPND of bilateral caudate nucleus and putamen dopamine D2 receptors in the MDD group were decreased(left caudate nucleus:1.16±0.37 vs 1.48±0.39,right caudate nucleus:1.21±0.31 vs 1.62±0.48,left putamen:1.73±0.47 vs 2.21±0.66,right putamen:1.79±0.46 vs 2.17±0.65,t=3.66,-4.42,-3.68,-2.91,all P<0.001).Besides,FC of left caudate nucleus and left medial prefrontal lobes(4.38±1.31,2.35±0.48),left caudate nucleus and left middle frontal gyrus(3.36±1.11,1.64±0.56),left caudate nucleus and left superior frontal gyrus(3.14±0.78,1.64±0.53),left putamen and left medial prefrontal lobes(4.10±1.42,2.42±0.64,t=6.82,P<0.05),right caudate nucleus and right medial prefrontal lobes(4.32±1.30,2.33±0.63,t=8.51,P<0.05),right putamen and right medial prefrontal lobes(3.77±1.25,2.31±0.63,t=6.49,P<0.05)in the MDD group were increased.FC of left putamen and left anterior cingulate(1.60±0.55,2.68±0.84,t=-6.76,P<0.05),right caudate nucleus and right amygdala(1.67±0.57,3.46±0.64,t=-8.27,

关 键 词：抑郁症 正电子发射断层显像术 计算断层扫描 功能磁共振成像 功能连接 

分 类 号：R749.4[医药卫生—神经病学与精神病学]