低剂量氨酚羟考酮片对非小细胞肺癌合并骨转移中度癌痛患者的应用效果分析  

Effect of low-dose oxycodone and acetaminophen tablets on non-small cell lung cancer patients combined with bone metastasis and moderate cancer pain

作　　者：赵小兰 程燕 熊洪 Zhao Xiaolan;Cheng Yan;Xiong Hong(Department of Respiratory Medicine,Affiliated Hospital of Southwest Medical University,Sichuan,Luzhou 646000,China)

机构地区：[1]西南医科大学附属医院呼吸内一科,四川泸州646000

出　　处：《中国医学前沿杂志（电子版）》2020年第7期151-155,共5页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

摘　　要：目的探讨低剂量氨酚羟考酮片对非小细胞肺癌(non-small cell lung cancer,NSCLC)合并骨转移中度癌痛患者的应用效果。方法选取2018年1月至2019年3月西南医科大学附属医院收治的86例NSCLC合并骨转移中度癌痛患者为研究对象,采用随机数字表法将其分为观察组和对照组,每组各43例。对照组患者给予盐酸曲马多缓释片镇痛治疗,观察组患者给予氨酚羟考酮片镇痛治疗。比较两组患者干预前后数字评分量表(numeric rating scale,NRS)评分、镇痛疗效、肺癌生存质量测定量表(function assessment of cancer therapy-lung,FACT-L)中文版(V4.0)评分和不良反应发生情况。结果干预后24 h、72 h、7 d、14 d,两组患者NRS评分均显著低于干预前(均P<0.05),观察组患者上述时间点NRS评分均显著低于同期对照组(均P<0.05);观察组患者短期镇痛总有效率显著高于对照组(P<0.05);干预后14 d,两组患者FACT-L中文版(V4.0)中FACT的一般模块(FACT-general module,FACT-G)、肺癌特异模块评分和总分均显著高于干预前(均P<0.05),观察组患者FACT-L中文版(V4.0)中FACT-G、肺癌特异模块评分与总分均显著高于对照组(均P<0.05);两组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论低剂量氨酚羟考酮能显著缓解NSCLC合并骨转移中度癌痛患者的疼痛,提高生存质量,疗效优于曲马多,安全可靠,值得临床推广应用。Objective To explore the effect of low-dose oxycodone and acetaminophen tablets on patients with non-small cell lung cancer(NSCLC)combined with bone metastasis and moderate cancer pain.Method A total of 86 patients with NSCLC with bone metastasis and moderate cancer pain admitted to Affiliated Hospital of Southwest Medical University from January 2018 to March 2019 were selected as the research subjects,and were divided into observation group and control group by random number table method,with 43 patients in each group.Patients in control group were given tramadol hydrochloride sustained-release tablets,while patients in observation group were given oxycodone and acetaminophen tablets.The numeric rating scale(NRS),analgesic efficacy,the Chinese version of function assessment of cancer therapy-lung(FACT-L)(V4.0)and adverse reactions were compared between two groups before and after intervention.Result At 24 h,72 h,7 d and 14 d after intervention,NRS scores in both groups were significantly lower than before intervention(all P<0.05),and the NRS scores of patients in observation group were significantly lower than those in control group at the above time points(all P<0.05).The total effective rate of short-term analgesia in observation group was significantly higher than that in control group(P<0.05).At 14 d after the intervention,the scores of FACT-general module(FACT-G),lung cancer specific module and total scores of FACT-L(V4.0)were significantly higher than those before the intervention(all P<0.05),and the scores of FACT-G,lung cancer specific module and total scores of FACT-L(V4.0)of observation group were significantly higher than those of control group(all P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Low-dose oxycodone and acetaminophen can significantly relieve the pain of NSCLC patients with bone metastasis and moderate cancer pain,improve the quality of life,and the efficacy is better than tramadol,which is safe a

关 键 词：氨酚羟考酮 癌痛 非小细胞肺癌 曲马多 生存质量 

分 类 号：R734.2[医药卫生—肿瘤]