高压氧联合放化疗对乳腺癌患者免疫功能及预后的影响  

Effects of hyperbaric oxygen combined with radiochemotherapy on immune function in patients with breast cancer and its prognosis

作　　者：薛登峰[1] 侯睿宏 郭向阳[1] 李炘正[1] Xue Dengfeng;Hou Ruihong;Guo Xiangyang;Li Xinzheng(Department of Breast Surgery,Shanxi Provincial Cancer Hospital,Taiyuan 030001,China)

机构地区：[1]山西省肿瘤医院乳腺外科,太原030001 [2]山西白求恩医院风湿免疫科

出　　处：《中华航海医学与高气压医学杂志》2020年第3期334-337,共4页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

摘　　要：目的探究高压氧(HBO)联合放化疗对乳腺癌患者免疫功能及预后的影响。方法选取2017年6月至2018年12月山西省肿瘤医院乳腺外科收治的乳腺癌患者144例作为研究对象,按照数字表法随机分为对照组(n=72)和观察组(n=72)。对照组给予常规放化疗,观察组在对照组治疗的基础上予以HBO辅助治疗。比较2组患者治疗前后免疫球蛋白IgG、IgM及补体C3、C4的水平,同时检测CD3^+、CD4^+及CD8^+T淋巴细胞的变化;随访1年,比较2组患者不良反应、并发症、肿瘤复发及转移情况。结果治疗6个疗程后,观察组患者免疫球蛋白IgG、IgM及补体C3、C4水平显著高于对照组,差异均有统计学意义(P<0.05);且CD4^+T淋巴细胞计数较对照组也明显升高(P<0.05)。随访1年发现,观察组患者骨髓毒性、消化道反应及脱发等不良反应改善明显优于对照组,且复发及转移发生率显著低于对照组,差异均有统计学意义(P<0.05或P<0.01)。结论HBO辅助治疗可有效提高乳腺癌患者放化疗后的免疫功能,减少不良反应的发生,并延缓肿瘤的复发及转移。Objective To explore the effects of hyperbaric oxygen(HBO)combined with radiochemotherapy on the immune function and prognosis of patients with breast cancer.Methods A total of 144 breast cancer patients admitted in the Department of Breast Surgery,Shanxi Provincial Cancer Hospital from June 2017 to December 2018 were selected as the research objects and randomly divided into control group(n=72)and observation group(n=72)according to random number table method.The control group was given the conventional radiochemotherapy treatment,and the observation group was treated with the hyperbaric oxygen(HBO)therapy on the basis of the treatment in the control group.The changes of the immunoglobulin(IgG and IgM)and their complements(C3 and C4),CD3^+,CD4^+,and CD8^+T lymphocytes of the two groups were compared before and after the treatment.The adverse reactions,complications,tumor recurrence and metastasis of the patients in the two groups were compared in a 1-year follow-up.Results After 6 courses of the treatment,the immunoglobulin(IgG and IgM)and their complements(C3 and C4)levels of the patients in the observation group were significantly higher than those in the control group.The difference was statistically significant(P<0.05).CD4^+T lymphocyte count was also obviously higher than that of the control group(P<0.05).One-year follow-up showed that the bone marrow toxicity,gastrointestinal reaction,and hair loss of the patients in the observation group were significantly better than those in the control group,and the incidences of breast cancer recurrence and metastasis were significantly lower than those in the control group with statistically significant difference(P<0.05 or P<0.01).Conclusion HBO therapy,as an assisting treatment,can effectively enhance the immunity of breast cancer patients after radiochemotherapy,reduce the occurrence of adverse reactions,and delay tumor recurrence and metastasis.

关 键 词：高压氧 放化疗 乳腺癌 免疫功能 肿瘤复发 

分 类 号：R737.9[医药卫生—肿瘤]