差异蛋白质组学在肝纤维化疾病中的应用  

Application of differential proteomics in hepatic fibrosis

作　　者：蒋云霞[1] 罗伟生[1] JIANG Yun-xia;LUO Wei-sheng(Guangxi University of Traditional Chinese Medicine,Nanning 530001,China)

机构地区：[1]广西中医药大学,广西南宁530001

出　　处：《生物技术》2020年第3期302-306,共5页Biotechnology

基　　金：国家自然科学基金项目(“基于系统生物学的荔枝核总黄酮对肝星状细胞作用靶点及信号转导通路研究”,81660779);2018年广西一流学科建设项目重点课题(“基于MAPK信号转导通路对大鼠肝纤维化的影响及荔枝核总黄酮的干预效应机制”,2018XK035)。

摘　　要：差异蛋白质组学作为一种新兴的蛋白质研究技术,逐渐在肝纤维化(HF)疾病的研究中广泛应用。该文主要对差异蛋白组学的理论基础、在肝纤维化疾病的诊治和研究技术上的应用以及目前存在的问题等方面作一简要综述,从而阐明在肝纤维化疾病中差异蛋白组学现阶段的研究现状,旨在为探讨如何更全面完整地研究肝纤维化提供参考。随着科学技术及科研条件的不断完善,差异蛋白组学的多种技术手段应用于肝纤维化疾病将具有更广阔的研究前景和发展空间。As a new protein research technology,differential proteomics plays an important role in the study of hepatic fibrosis(HF).This paper mainly describes the theoretical basis of differential proteomics,the application of differential proteomics in the diagnosis,treatment and research of HF,as well as the existing problems.In this way,we can show the current research status of differential proteomics in HF,in order to provide a reference for further study of it.With the continuous improvement of technology and scientific research conditions,the application of differential proteomics to HF will have a broader research prospect and far-reaching development.

关 键 词：差异蛋白组学 肝纤维化 双向电泳 i TRAQ技术 生物质谱 

分 类 号：R575.2[医药卫生—消化系统]