伊布利特对肿瘤患者急性房颤的疗效与安全性  

Efficacy and safety of ibutilide for cardioversion of acute atrial fibrillation in patients with cancer

作　　者：宋欢欢[1] 王玉华[1] 陈焕玲 刘红玲 SONG Huanhuan;WANG Yuhua;CHEN Huanling;LIU Hongling(Department of Emergency,Kaiyuan Branch of the First Affiliated Hospital of He’nan University of Science and Technology,Luoyang 471000,He’nan,China)

机构地区：[1]河南科技大学第一附属医院开元院区急诊科,河南洛阳4710000

出　　处：《癌症进展》2020年第13期1334-1336,1344,共4页Oncology Progress

摘　　要：目的观察伊布利特对肿瘤患者急性房颤的疗效与安全性。方法依据治疗方法将82例急诊科就诊的发生急性房颤的肿瘤患者分为治疗组和对照组,每组41例,治疗组患者接受伊布利特治疗,对照组患者接受胺碘酮治疗。比较两组患者药物转复的成功率、转复后的血压、心电图、肝肾功能等。结果两组患者药物治疗后,共56例(68.3%)患者转复成功,其中治疗组患者转复成功率80.5%,高于对照组患者的56.1%,差异有统计学意义(P<0.05)。治疗后,治疗组患者校正后的QTc短于对照组,且治疗组无超过440 ms(男)或450 ms(女)的QTc,两组患者的QTc均长于基线水平,其中治疗组患者的QTc与治疗前比较,差异无统计学意义(P> 0.05),对照组患者的QTc与治疗前比较,差异有统计学意义(P<0.05)。两组患者转复后血压、谷丙转氨酶(ALT)、肌酐(Cr)比较,差异均无统计学意义(P> 0.05);复查肝肾功能,未发现明显肝肾功能损伤。结论伊布利特转复恶性肿瘤患者急性房颤的效果和安全性均较好。Objective To observe the efficacy and safety of ibutilide for chemical cardioversion of acute atrial fibrillation in patients with cancer.Method According to the treatment methods,82 cases of tumor patients with acute atrial fibrillation were divided into treatment group and control group,41 cases in each group,study group patients were treated with ibutilide while control group ones were treated with amiodarone,respectively.The success rate of chemical cardioversion,post-cardioversion blood pressure,electrocardiogram,hepatic and renal function of the two groups of patients were compared.Result After medication treatments,a total of 56(68.3%) patients had successful cardioversion,and the success rate was 80.5% in study group,which was significantly higher compared to the 56.1% in control group(P<0.05).After treatment,the corrected QT interval(QTc) was shorter in study group than in control group,furthermore,there were no patients in study group with QTc exceeding 440 ms(males) or 450 ms(females),besides,the QTc in both groups were prolonged from baseline,though the difference observed in study group was of no statistical significance(P>0.05),while it was evidently different for control group(P<0.05).The post-cardioversion blood pressure,alanine aminotransferase(ALT) and creatinine(Cr) were similar between the two groups(P>0.05);and there were no marked hepatic or renal dysfunction identified in reexamination.Conclusion Ibutilide is effective and safe for cancer patients in ameliorating acute atrial fibrillation.

关 键 词：伊布利特 肿瘤 房颤 

分 类 号：R737.1[医药卫生—肿瘤]