相同单体核型恶性血液病二例治疗体会并文献复习  

Treatment of hematologic malignancies with same monosomal karyotype:Report of two cases and review of the literature

作　　者：白观臣[1] 刘玉玉[1] 高苗苗 高思凤[1] 张继磊 滕清良[1] Bai Guanchen;Liu Yuyu;Gao Miaomiao;Gao Sifeng;Zhang Jilei;Teng Qingliang(Deparment of Hematologhy,the Tai′an City Center Hospital,Tai′an 271000,China)

机构地区：[1]泰安市中心医院血液内科,271000

出　　处：《中华临床医师杂志（电子版）》2020年第7期569-572,共4页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：目的 报道2例del(5)恶性血液病的不同治疗过程,通过文献复习探讨不同治疗方式.方法 分别采用雷利度胺及地西他滨为基础的治疗方案,观察患者的血象、临床表现及细胞遗传学的变化.结果 2例患者采用不同的治疗方案,均获得细胞遗传学缓解.结论 相同的单体核型在不同疾病具有不同的预后价值,依据指南治疗才能取得良好效果.Objective To assess the therapeutic effects of different regimens in two hematologic malignancy patients with del(5)and perform a review of the literature.Methods The changes of blood para,clinical manifestations,and cytogenetics were investigated in two patients with hematologic malignancies who were treated with lenalidomide and decitabine-based regimens,respectively.Results Although the two patients received different treatments,they both achieved cytogenetic remission.Conclusion The same monosomal karyotype may predict different prognoses in different diseases,and treatment based on guidelines should be adopted in order to achieve good results.

关 键 词：核型分析 预后 雷利度胺 地西他滨 

分 类 号：R733.7[医药卫生—肿瘤]