乳腺癌新辅助化疗前后钙化改变的临床应用价值  

Clinical value of calcification afterneoadjuvant chemotherapy in breast cancer

作　　者：赵慧娟[1] 刘香玉 尹成方[1] ZHAO Huijuan;LIU Xiangyu;YIN Chengfang(Department of Radiology,Liaocheng People’s Hospital,Liaocheng 252000,Shandong Province,China;Department of Medical Imaging,Jinan Women and Children’s Health Institute,Jinan 250000,Shandong Province,China)

机构地区：[1]山东省聊城市人民医院放射科,山东聊城252000 [2]山东省济南市妇幼保健院,山东济南250000

出　　处：《肿瘤影像学》2020年第3期258-264,共7页Oncoradiology

摘　　要：目的:探究乳腺癌新辅助化疗前后钙化变化与肿瘤病理学[Miller&Payen分类(MP)]分级的关系。方法:回顾并分析88例乳腺癌患者新辅助化疗前后钙化数量的变化与钙化形态的关系。结果:88例乳腺癌患者符合标准并进行新辅助化疗后,23例患者钙化数量减少,55例患者钙化数量保持稳定,10例患者钙化数量增多。新辅助化疗后钙化数量减少的患者较钙化保持稳定的患者病理完全缓解率高,钙化数量减少的患者化疗反应MP分级为Ⅳ和Ⅴ的比例为87.0%;钙化数量增加的患者化疗反应MP分级为Ⅰ和Ⅱ的比例为80.0%。钙化数量减少的患者中钙化仅分布在肿块内的患者比例为69.6%,钙化数量增加的患者中则不存在此类型。新辅助化疗后钙化减少的患者中细小多形性、细线或细线分支样钙化所占比例较高(78.3%)。结论:新辅助化疗后钙化数目的变化与化疗反应MP分级、钙化的分布及钙化的形态存在密切联系,但大部分乳腺癌患者新辅助化疗后钙化保持稳定。Objective:To investigate the relationship between the change of microcalcification and tumor pathological response after neoadjuvant chemotherapy in breast cancer.Methods:The changes of calcification amount and its relationship with calcification morphology before and after neoadjuvant chemotherapy in 88 breast cancer patients were analyzed retrospectively.Results:88 cases of breast cancer meet the standard,and after neoadjuvant chemotherapy,23 cases of patients whose number of calcification were reduced;55 patients remained stable,10 cases increased.Patients whose number of calcification were reduced after neoadjuvant chemotherapy had higher rates of pathological complete remission than patients with stable calcification.Patients whose Miller&Payen(MP)classification wereⅣandⅤwere 87.0%in patients with reduced number of calcification.Patients whose MP classification wereⅠandⅡwere 80.0%in patients with increased number of calcification.In cases of whose calcification number were reduced,there were 69.6%patients whose calcification was only distributed in the mass,and cases of whose calcification number were increased had no type like this(the number of calcified lesions was not distributed in the mass).The proportion of small pleomorphic and thin or thin branched calcification in patients whose number of calcification were decreased after neoadjuvant chemotherapy was 78.3%.Conclusion:The changes of the number of calcifications after neoadjuvant chemotherapy had relationship with MP classification,the distribution of calcification and the morphology of calcification.But calcification remained stable in most breast cancer patients after neoadjuvant chemotherapy.

关 键 词：乳腺癌 新辅助化疗 乳腺X线摄影 钙化 

分 类 号：R737.9[医药卫生—肿瘤] R445.4[医药卫生—临床医学]