左旋咪唑联合维生素B12治疗复发性口腔溃疡的疗效探讨  

Efficacy of levamisole combined with Vitamin B12 in the treatment of recurrent oral ulcer

作　　者：李艳红 邸坤燕 张茹梅 Li Yanhong;Di Kunyan;Zhang Rumei(Qinhuangdao Fourth Hospital Pharmacy,Qinhu angdao hebei 066000;Qinhuangdao Fourth Hospital Stomatology,Qinhu angdao hebei 066000;Qinhuangdao Fourth Hospital Surgery,Qinhu angdao hebei 066000)

机构地区：[1]秦皇岛市第四医院药剂科,河北秦皇岛066000 [2]秦皇岛市第四医院口腔科,河北秦皇岛066000 [3]秦皇岛市第四医院外科,河北秦皇岛066000

出　　处：《当代医药论丛》2020年第12期105-106,共2页

摘　　要：目的:探讨用左旋咪唑联合维生素B12对复发性口腔溃疡患者进行治疗的临床效果。方法:选取2017年1月至2018年12月期间秦皇岛市第四医院收治的120例复发性口腔溃疡患者为研究对象。将其随机分为观察组和对照组。单纯应用左旋咪唑对对照组患者进行治疗,应用左旋咪唑联合维生素B12对观察组患者进行治疗。治疗30 d后,对比两组患者溃疡面愈合的时间、疼痛的程度及生活质量的改善情况。结果:治疗后,与对照组患者相比,观察组患者溃疡面愈合的时间较短,其VAS评分较低,其QOL-74各维度的评分均较高,P<0.05。结论:应用左旋咪唑联合维生素B12对复发性口腔溃疡患者进行治疗可显著缩短其溃疡面愈合的时间,减轻其疼痛的程度,提高其生活质量。Objective:To investigate the clinical effect of levamisole combined with vitamin B12 in the treatment of recurrent oral ulcer.Methods:120 patients with recurrent oral ulcer were selected from Qinhuangdao Fourth Hospital from January 2017 to December 2018.They were randomly divided into observation group and control group.The control group was treated with levamisole alone,while the observation group was treated with levamisole combined with vitamin B12.After 30 days of treatment,the time of ulcer healing,pain degree and improvement of life quality were compared between the two groups.Results:After treatment,compared with the control group,patients in the observation group had a shorter healing time of ulcer surface,a lower VAS score,and a higher QOL-74 score in all dimensions(P<0.05).Conclusion:Levamisole combined with vitamin B12 can significantly shorten the healing time of recurrent oral u lcer,reduce the pain and improve the quality of life.

关 键 词：左旋咪唑 维生素B12 复发性口腔溃疡 生活质量 

分 类 号：R781.55[医药卫生—口腔医学]