终末期肝病患者的肝储备功能与其Meld评分的相关性  

Analysis of the correlation between liver reserve function and Meld score in patients with end-stage liver disease

作　　者：龙黎 熊晏[1] 罗新华[1] Long Li;Xiong Yan;Luo Xinhua(Guizhou Provincial People’s Hospital,Guiyang,Guizhou 550000)

机构地区：[1]贵州省人民医院,贵州贵阳550000

出　　处：《当代医药论丛》2020年第12期156-158,共3页

摘　　要：目的:分析终末期肝病患者的肝储备功能与其Meld(终末期肝病模型)评分的相关性。方法:选取2015年1月至2017年12月期间在贵州省人民医院接受诊治的100例终末期肝病患者作为研究对象。根据病情的不同,将这100例患者分为慢性肝炎组(n=50)及肝炎代偿期组(n=50)。对这两组患者均进行吲哚氰绿(ICG)排泄试验、肝脏纤维化定性实验及肝脏硬度检测。然后,比较两组患者的15 min血中ICG滞留率(ICGR15值)、ICG血中清除率(ICGK值)及肝脏硬度值;比较Meld评分不同的患者其肝脏纤维化的面积。结果:慢性肝炎组患者的ICGR15值及肝脏硬度值均低于肝炎代偿期组患者,其ICGK值高于肝炎代偿期组患者,P<0.05。Meld评分≥26分的患者其肝脏纤维化的面积大于Meld评分为16~25分的患者;Meld评分≥26分的患者其肝脏纤维化的面积大于Meld评分为10~15分的患者;Meld评分为16~25分的患者其肝脏纤维化的面积大于Meld评分为10~15分的患者,P<0.05。结论:终末期肝病患者肝脏纤维化的面积越大,其肝脏的储备功能越差。Objective:To analyze the correlation between liver reserve function and Meld(model of end-stage liver disease)score in patients with end-stage liver disease.Methods:100 patients with end-stage liver disease who received treatment in Guizhou Provincial People’s Hospital from January 2015 to December 2017 were selected as the research objects.The 100 patients were divided into chronic hepatitis group(n=50)and compensatory hepatitis group(n=50)according to their conditions.Indocyanine green(ICG)excretion test,liver fibrosis qualitative test and liver hardness test were performed in both groups.Then,ICG retention rate(ICGR15 value),ICG clearance rate(ICGK value)and liver hardness values of the two groups were compared.The area of hepatic fibrosis in patients with different Meld scores was compared.Results:The ICGR15 value and liver hardness value of patients in chronic hepatitis group were lower than those in the compensatory period of hepatitis,and the ICGK value was higher than that in the compensatory period of hepatitis group(P<0.05).The area of liver fibrosis in patients with Meld score≥26 was larger than that in patients with Meld score ranging from 16 to 25.The area of liver fibrosis in patients with Meld score≥26 was larger than that in patients with Meld score of 10-15.The area of hepatic fibrosis in patients with Meld score of 16~25 was larger than that in patients with Meld score of 10~15,P<0.05.Conclusion:In patients with end-stage liver disease,the larger the area of fibrosis,the p oorer the reserve function of the liver.

关 键 词：终末期肝病 肝储备功能 MELD评分 肝脏纤维化定性实验 

分 类 号：R575[医药卫生—消化系统]