Nanozymes: created by learning from nature  

作　　者：Ruofei Zhang Kelong Fan Xiyun Yan 

机构地区：[1]CAS Engineering Laboratory for Nanozyme,Key Laboratory of Protein and Peptide Pharmaceutical,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China [2]Joint Laboratory of Nanozymes in Zhengzhou University,Academy of Medical Sciences,Zhengzhou University,Zhengzhou 450052,China

出　　处：《Science China(Life Sciences)》2020年第8期1183-1200,共18页中国科学（生命科学英文版）

基　　金：financially supported by the National Natural Science Foundation of China(31871005,31530026,and 31900981);Chinese Academy of Sciences(YJKYYQ20180048),the Strategic Priority Research Program(XDB29040101);the Key Research Program of Frontier Sciences(QYZDY-SSW-SMC013);Chinese Academy of Sciences and National Key Research and Development Program of China(2017YFA0205501);Youth Innovation Promotion Association CAS(2019093)。

摘　　要：Nanozymes,a type of nanomaterials with enzyme-like activity,have shown great potential to replace natural enzymes in many fields such as biochemical detection,environmental management and disease treatment.However,the catalytic efficiency and substrate specificity of nanozymes still need improvement.To further optimize the enzymatic properties of nanozymes,recent studies have introduced the structural characteristics of natural enzymes into the rational design of nanozymes,either by employing small molecules to mimic the cofactors of natural enzymes to boost nanozymes’catalytic potential,or by simulating the active center of natural enzymes to construct the nanostructure of nanozymes.This review introduces the commonly used bio-inspired strategies to create nanozymes,aiming at clarifying the current progress and bottlenecks.Advances and challenges focusing on the research of bio-inspired nanozymes are outlined to provide ideas for the de novo design of ideal nanozymes.

关 键 词：BIO-INSPIRED nanozyme enzyme-like activity bio-mimic active center COFACTORS single-atom catalysis 

分 类 号：Q814[生物学—生物工程] TB383.1[一般工业技术—材料科学与工程]