COFACTORS

作品数：22被引量：65H指数：5
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相关领域：生物学医药卫生更多>>
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相关机构：华中科技大学更多>>
相关期刊：《Science China(Life Sciences)》《Science China Chemistry》《Virologica Sinica》《Journal of Mathematical Research with Applications》更多>>
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Autoinhibition and cofactors of a helper NLR
《Science China(Life Sciences)》2025年第3期890-892,共3页Hongyuan Zheng Xuemin Zhou Chenyu Zhao Daowen Wang Zhengqing Fu 
supported by the National Science Foundation(IOS-2207677);the key research and development grant from Henan Province(232102111078).
Plants offer a plethora of benefits to human existence.However,in the natural world,plants encounter numerous biotic and abiotic pressures,including the presence of various pathogens that cause serious diseases on cro...
关键词：IMMUNITY diseases CROPS 
Extensions of the Graham-Hoffman-Hosoya Type Theorems for the Exponential Distance Matrices and q-Distance Matrices
《Journal of Mathematical Research with Applications》2024年第6期723-734,共12页Jie WANG 
Let G be a strongly connected directed weighted graph with vertex set{v_(1),v_(2),...,v_(n)},in which each edge e is assigned with an arbitrary nonzero weight w(e).For any two vertices v_i,v_(j )of G,the distance d_(i...
关键词：distance matrices exponential distance matrices q-distance matrices determinants COFACTORS cofactor sums 
Molecular Basis of KAT2A Selecting Acyl-CoA Cofactors for Histone Modifications
《Research》2024年第2期105-109,共5页Sha Li Nan Li Jie He Runxin Zhou Zhimin Lu Yizhi Jane Tao Yusong R.Guo Yugang Wang 
supported by National Natural Science Foundation of China(91957110,31970577,and 32270642 to Y.W.,32170597 to Y.R.G.)。
Emerging discoveries about undocumented acyltransferase activities of known histone acetyltransferases(HATs)advance our understandings in the regulation of histone modifications.However,the molecular basis of HATs sel...
关键词：utilize selecting ELECTROSTATIC 
Molecular Basis of KAT2A Selecting Acyl-CoA Cofactors for Histone Modifications
《Research》2023年第4期577-581,共5页Sha Li Nan Li Jie He Runxin Zhou Zhimin Lu Yizhi Jane Tao Yusong R.Guo Yugang Wang 
This work was supported by National Natural Science Foundation of China(91957110,31970577,and 32270642 to Y.W.;32170597 to Y.R.G.)。
Emerging discoveries about undocumented acyltransferase activities of known histone acetyltransferases(HATs)advance our understandings in the regulation of histone modifications.However,the molecular basis of HATs sel...
关键词：utilize selecting ELECTROSTATIC 
A biologically stable, self-catalytic DNAzyme machine encapsulated by metal-phenolic nanoshells for multiple microRNA imaging被引量：1
《Chinese Chemical Letters》2023年第10期197-203,共7页Xin Jin Qin Wang Jiezhou Pan Jin Wang Yunxiang He Jiaojiao Shang Mei Chen Xianglian He Yaoyao Zhang Bo Wang Yajie Wang Guidong Gong Junling Guo 
supported by National Talents Program,Double First Class University Plan of Sichuan University,State Key Laboratory of Polymer Materials Engineering(No.sklpme 2020-0301);Natural Science Foundation of Sichuan Province(Nos.2022NSFSC1735,2023NSFSC1097);Fundamental Research Funds for the Central Universities(No.ZYN2022094);National Natural Science Foundation of China(Nos.22178233,22208228);China Postdoctoral Science Foundation(No.2020TQ0209);Fundamental Research Funds for the Central Universities(No.YJ201959);Science and Technology Support Program of Sichuan Province(No.2021YJ0414);Project of Chengdu Science and Technology Bureau(No.2021YF05-02110-SN)。
DNAzyme machines play critical roles in the fields of cell imaging, disease diagnosis, and cancer therapy. However, the applications of DNAzyme machines are limited by the nucleases-induced degradation,non-specific bi...
关键词：DNAzyme machine Metal-phenolic nanoshells Interference protection Cofactors self-supply Cell imaging 
Radical SAM-Dependent Demetallation of Heme被引量：2
《Chinese Journal of Chemistry》2022年第9期1053-1058,共6页Jinduo Cheng Wei Ding Qi Zhang 
This work is supported by grants from the National Key Researchand Development Program(2021YFA0910501 and 2018YFA0900402);the National Natural Science Foundation of China(21822703,21921003,and 32070050);the funding of Innovative Research Team of High-level Local Universities in Shanghai and a key laboratory program of the Education Commission of Shanghai Municipality(ZDSYS14005).
Demetallation of heme to release iron is a chemical difficult reaction and is highly rare in biochemistry,with apoferritin as the only known enzyme responsible for this process.Here we show the heme degradation enzyme...
关键词：BIOSYNTHESIS BIOTRANSFORMATIONS COFACTORS Enzymes HEMIN 
Interplay between cofactors and transcription factors in hematopoiesis and hematological malignancies被引量：3
《Signal Transduction and Targeted Therapy》2021年第2期409-424,共16页Zi Wang Pan Wang Yanan Li Hongling Peng Yu Zhu Narla Mohandas Jing Liu 
This work was supported by the grants from National Key Research and Development Program of China(Grant number 2108YFA0107800);National Natural Science Foundation of China(Grant numbers 81920108004,81770107,81702722,81470362 and 81700168);National Postdoctoral Program for Innovative Talents(Grant number BX201700292);Natural Science Foundation of Hunan Province(Grant num ber 2018JJ3703);Science and Technology Key Project of Hunan Province(Grant number 2018SK21212);Fundamental Research Funds for the Central Universities of Central South University(Grant number 2018zzts386).
Hematopoiesis requires finely tuned regulation of gene expression at each stage of development.The regulation of gene transcription involves not only individual transcription factors(TFs)but also transcription complex...
关键词：HEMATOPOIESIS COFACTOR LANDSCAPE 
Nanozymes: created by learning from nature被引量：20
《Science China(Life Sciences)》2020年第8期1183-1200,共18页Ruofei Zhang Kelong Fan Xiyun Yan 
financially supported by the National Natural Science Foundation of China(31871005,31530026,and 31900981);Chinese Academy of Sciences(YJKYYQ20180048),the Strategic Priority Research Program(XDB29040101);the Key Research Program of Frontier Sciences(QYZDY-SSW-SMC013);Chinese Academy of Sciences and National Key Research and Development Program of China(2017YFA0205501);Youth Innovation Promotion Association CAS(2019093)。
Nanozymes,a type of nanomaterials with enzyme-like activity,have shown great potential to replace natural enzymes in many fields such as biochemical detection,environmental management and disease treatment.However,the...
关键词：BIO-INSPIRED nanozyme enzyme-like activity bio-mimic active center COFACTORS single-atom catalysis 
Study of Cofactors Associated with Precancerous High-Grade Cervical Lesions at the Teaching Hospital Gabriel Touré, 2010 to 2015
《Surgical Science》2019年第9期328-337,共10页Fané Seydou Bocoum Amadou Sissoko Abdoulaye Traoré Soumana Oumar Sanogo Siaka Amara Mamadou Sima Kouma Aminata Traoré Alassane Tegueté Ibrahima Traoré Youssouf Mounkoro Niani 
Introduction: High grade dysplasia of the cervix has a high incidence and can progress to cervical cancer. The aim was to study cofactors associated with high-grade cervical dysplasia. Methodology: This was a retrospe...
关键词：High Grade Dysplasia COFACTOR Cervical Cancer Teaching Hospital GABRIEL Touré 
FOXP3 and Its Cofactors as Targets of Immunotherapies被引量：2
《Engineering》2019年第1期115-121,共7页Yasuhiro Nagai Lian Lam Mark I. Greene Hongtao Zhang 
grant supports from the Breast Cancer Research Foundation and the National Institutes of Health to M.I.Greene(RO1CA219034)
Forkhead box P3 (FOXP3) is a “master regulator” of regulatory T cells (Tregs), which are a subset of T cells that can suppress the antigen-specific immune reaction and that play important roles in host tolerance and...
关键词：Treg FORKHEAD box P3 (FOXP3) POST-TRANSLATIONAL modification AUTOIMMUNE Cancer 
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