BIOTRANSFORMATIONS

作品数：9被引量：11H指数：2
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Characterization of HpnG as a Purine Nucleoside Phosphorylase in Bacteriohopanepolyol Biosynthesis
《Chinese Journal of Chemistry》2024年第19期2351-2356,共6页Xinhui Li Xiaoyu Zhu Yuting Zhong Wei Zhang Fener Chen Wenning Wang Wei Ding Qi Zhang 
supported by grants from the National Key Research andDevelopmenttProgram(2018YFA0900402,2021YFA0910501);the National Natural Science Foundation of China(21921003,32270070,32270050,U22A20451);the Funding of Innovative Research Team of High-Level Local Universities in Shanghai and a key laboratory program of the Education Commission of Shanghai Municipality(ZDSYS14005);West Light Foundation of The Chinese Academy of Sciences(xbzg-zdsys-202105).
Comprehensive Summary HpnG plays a crucial role in the production of ribosylhopane,a key intermediate in the biosynthesis of bacteriohopanepolyol.Despite early extensive studies,the precise function of HpnG has remain...
关键词：ENZYMES Enzyme catalysis NUCLEOSIDES BIOSYNTHESIS Natural products LIPIDS Phosphorolysis BIOTRANSFORMATIONS 
Metabolomic studies in the inborn error of metabolism alkaptonuria reveal new biotransformations in tyrosine metabolism被引量：1
《Genes & Diseases》2022年第4期1129-1142,共14页Brendan P.Norman Andrew S.Davison Juliette H.Hughes Hazel Sutherland Peter J.M.Wilson Neil G.Berry Andrew T.Hughes Anna M.Milan Jonathan C.Jarvis Norman B.Roberts Lakshminarayan R.Ranganath George Bou-Gharios James A.Gallagher 
BPN is funded by the University of Liverpool,Royal Liverpool University Hospitals Trust and Agilent Technologies UK Ltd.ASD is funded through a National Institute for Health Research Doctoral Research Fellowship(No.HCS DRF-2014-05-009).
Alkaptonuria (AKU) is an inherited disorder of tyrosine metabolism caused by lack of active enzyme homogentisate 1,2-dioxygenase (HGD). The primary consequence of HGD deficiency is increased circulating homogentisic a...
关键词：ALKAPTONURIA BIOTRANSFORMATION METABOLISM Metabolomics Mice 
Consecutive Methylation Catalyzed by TsrM,an Atypical Class B Radical SAM Methylase被引量：1
《Chinese Journal of Chemistry》2022年第14期1693-1698,共6页Runze Wu Wei Ding Qi Zhang 
supported by grants from the National Key Research and Development Program(2018YFA0900402 and 2021YFA0910501);the National Natural Science Foundation of China(21822703,21921003,and 32070050);the funding of Innovative research team of high-level local universities in Shanghai and a key laboratory program of the Education Commission of Shanghai Municipality(ZDSYS14005);West Light Foundation of The Chinese Academy of Sciences xbzg-zdsys-202105.
TsrM is a cobalamin-dependent radical S-adenosylmethionine(SAM)methyltransferase belonging to the Class B radical SAM methylase(RSM)family.This enzyme catalyzes the C-2 methylation of L-tryptophan to produce 2-methylt...
关键词：BIOSYNTHESIS BIOTRANSFORMATIONS Catalytic promiscuity Enzyme METHYLTRANSFERASE 
Radical SAM-Dependent Demetallation of Heme被引量：2
《Chinese Journal of Chemistry》2022年第9期1053-1058,共6页Jinduo Cheng Wei Ding Qi Zhang 
This work is supported by grants from the National Key Researchand Development Program(2021YFA0910501 and 2018YFA0900402);the National Natural Science Foundation of China(21822703,21921003,and 32070050);the funding of Innovative Research Team of High-level Local Universities in Shanghai and a key laboratory program of the Education Commission of Shanghai Municipality(ZDSYS14005).
Demetallation of heme to release iron is a chemical difficult reaction and is highly rare in biochemistry,with apoferritin as the only known enzyme responsible for this process.Here we show the heme degradation enzyme...
关键词：BIOSYNTHESIS BIOTRANSFORMATIONS COFACTORS Enzymes HEMIN 
Current Understanding toward Isonitrile Group Biosynthesis and Mechanism
《Chinese Journal of Chemistry》2021年第2期463-472,共10页Tzu-Yu Chen Jinfeng Chen Yijie Tang Jiahai Zhou Yisong Guo Wei-chen Chang 
This work is supported by the Harry C.Kelly Memorial Fund for U.S.-Japan Scientific Cooperation,through the Office of Global Engagement;the NC Japan Center,at NC State University,Natinnal Institute of Health(GM177588 to W.-c.Cr and Y.G.);MOST(2019YFA09005000 and 2018YFA0901900 to J.Z).
Isonitrile group has been identified in many natural products.Due to the broad reactivity of N≡C triple bond,these natural products have valuable pharmaceutical potentials.This review summarizes the current biosynthe...
关键词：BIOSYNTHESIS ENZYMES Natural products Reaction mechanisms BIOTRANSFORMATIONS 
A.Flavus Mediated Biotransformations for the Syntheses of Active A-oxyfunctionalized Compounds
《复旦学报（自然科学版）》2007年第5期739-,共1页P.Ayhan S.Betul Sopaci A.S.Demir 
1 Results Biotransformations are enzyme- and whole cell-catalysed conversions of non-natural substrates to products.They are important tools in organic synthesis,especially for the syntheses of chiral molecules,where ...
关键词：A.flavus whole-cell reaction BIOTRANSFORMATION α-hydroxy ketones 
Nitrile biotransformations for the practical synthesis of highly enantiopure azido carboxylic acids and amides, ‘click’ to functionalized chiral triazoles and chiral beta-amino acids被引量：3
《中国生物学文摘》2007年第3期30-30,共1页Ma, D. Y. Wang, D. X. Zheng, Q. Y. Wang, M. X. 
关键词：Β-氨基酸 三唑 腈 生物转化 合成 羧酸 氨基化合物 
Combined biotransformations of 4（20）,11-taxadienes
《中国生物学文摘》2007年第1期22-22,共1页Dai, J. G. Yang, L. Sakai, J. Ando, M. 
关键词：生物转化 细胞 银杏树 可识别性 
Recent Progress on Biocatalysis and Biotransformations in Ionic Liquids被引量：5
《Chinese Journal of Chemical Engineering》2004年第4期543-549,共7页娄文勇 宗敏华 吴虹 许若 
the Natural Science Foundation of Guangdong Province (No. 020839).
Ionic liquids have negligibly low vapor pressure, high stability and polarity. They are regarded as green solvents. Enzymes, especially lipases, as well as whole-cell of microbe, are catalytically active in ionic liqu...
关键词：ionic liquids biocatalysis and biotransformations enzymatic catalysis 
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