Current Understanding toward Isonitrile Group Biosynthesis and Mechanism  

作　　者：Tzu-Yu Chen Jinfeng Chen Yijie Tang Jiahai Zhou Yisong Guo Wei-chen Chang 

机构地区：[1]Department of Chemistry,North Carolina State University Raleigh,NC,27695 U.S.A [2]State Key Laboratory of Bio-organic and Natural Products Chemistry,Center for Excellence in Molecular Synthesis,Shanghai Institute of Organic Chemistry,University of Chinese Academy of Sciences,Shanghai,200032 China [3]Department of Chemistry,Carnegie Mellon University,Pittsburgh,PA,15213 U.S.A [4]CAS Key Laboratory of Quantitative Engineering Biology,Shenzhen Institute of Synthetic Biology,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen,Guangdong,518055 China

出　　处：《Chinese Journal of Chemistry》2021年第2期463-472,共10页中国化学（英文版）

基　　金：This work is supported by the Harry C.Kelly Memorial Fund for U.S.-Japan Scientific Cooperation,through the Office of Global Engagement;the NC Japan Center,at NC State University,Natinnal Institute of Health(GM177588 to W.-c.Cr and Y.G.);MOST(2019YFA09005000 and 2018YFA0901900 to J.Z).

摘　　要：Isonitrile group has been identified in many natural products.Due to the broad reactivity of N≡C triple bond,these natural products have valuable pharmaceutical potentials.This review summarizes the current biosynthetic pathways and the corresponding enzymes that are responsible for isonitrile-containing natural product generation.Based on the strategies utilized,two fundamentally distinctive approaches are discussed.In addition,recent progress in elucidating isonitrile group formation mechanisms is also presented.

关 键 词：BIOSYNTHESIS ENZYMES Natural products Reaction mechanisms BIOTRANSFORMATIONS 

分 类 号：O62[理学—有机化学]