In this study,we unveil a conceptual technology for fabricating artificial metalloenzymes(ArMs)by deeply integrating hemin into protein scaffolds via a protein refolding process,a method that transcends the convention...
supported by the National Natural Science Foundation of China(Nos.82172736,81972886,and 82172735];the State Key Laboratory of Systems Medicine for Cancer(No.ZZ94-2306)。
The platinum-based chemotherapy is a routine strategy for the treatment of ovarian cancer,while it is prone to chemoresistance in clinical,which hinders the treatment.Therefore,it is urgently needed to elucidate the u...
supported by the National Natural Science Foundation of China(U1904147,31700677,U20A20369,82272785);Henan Provincial Science and Technology Research Project(232102311172);Shenzhen Science and Technology Program(KQTD20190929173853397);“Pearl River Talent Plan”Innovation and Entrepreneurship Team Project of Guangdong Province(2019ZT08Y464);the Guangdong Basic and Applied Basic Research Foundation(2022B1515120085);Fostering Project for Young Teachers of Zhengzhou University(JC22851042)。
The immune checkpoint TIGIT/PVR blockade exhibits significant antitumor effects through activation of NK and CD8^(+)T cell-mediated cytotoxicity.Immune checkpoint blockade(ICB)could induce tumor ferroptosis through I...
supported by the National Natural Science Foundation of China(Nos.21864026,21605130);the Natural Science Foundation of Yunnan Province,China(Nos.2018FB016,2016FD017).
The insufficient internal resorption of iodide ions(I−)leads to thyroid disorders,such as goiter,hypothyroidism,and cretinism in adults.In this paper,a portable point-of-care testing(POCT)platform was developed for th...
supported by the National Natural Science Foundation of China(51502161 and 21706148);the Natural Science Foundation of Shandong Province(ZR2020ME041,ZR2022QB173);Joint Zibo-SDUT Fund(2019ZBXC358);Foundation of State Key Laboratory of Biobased Material and Green Papermaking,Qilu University of Technology(Shandong Academy of Sciences)(KF2019-06)
As a H_(2)O_(2)electrochemical biomimetic enzyme sensor,the stability,repeatability and sensitivity of hemin-based composites are closely connected with the loading of hemin on high-performance matrix.Herein,polypyrro...
Supported by The Science and Technology Project of General Administration of Quality Supervision,Inspection and Quarantine (2015IK126);The Science and Technology Project of Changsha City of Hunan Province of China (KQ1602124).
Mercury ion(Hg^(2+)),a highly noxious of heavy metalion,has detrimental effects on the ecological environment and human health.Herein,we have developed an exonuclease III(Exo III)assisted catalytic hairpin assembly fo...