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Hemin调控小鼠软骨细胞氧化应激的线粒体途径
《中国组织工程研究》2025年第6期1183-1191,共9页贺光辉 原杰 柯燕琴 丘小婷 张晓玲 
山西省重点研发项目(201903D321097),项目负责人:张晓玲。
背景:研究显示线粒体氧化应激在膝骨关节炎发生发展中具有重要作用,Hemin可以调控线粒体相关蛋白的表达。目的:研究Hemin对小鼠软骨细胞氧化应激的调控及其在膝骨关节炎中的干预作用及机制。方法:①体外细胞实验:提取C57BL/6小鼠的原代...
关键词:膝骨关节炎 HEMIN 氧化应激 线粒体 细胞凋亡 软骨损伤 
过渡金属离子Cu^(2+)对hemin/AOPAN纤维膜催化性能的影响
《安徽工程大学学报》2025年第1期38-43,共6页韩旭 陶云 袁欣 邓依聪 王鹏 凤权 
安徽省重点研究与开发计划项目(2022a05020069);安徽工程大学校级科研项目(xjky03201901);安徽工程大学科研项目制促进纺织服装类本科拔尖人才培养项目(FFBK202215)。
采用静电纺丝法制备基于聚丙烯腈纳米纤维的氯化血红素催化材料(hemin/PAN纤维膜),并经偕胺肟改性和Cu^(2+)离子金属配位反应分别获得hemin/AOPAN和Cu-hemin/AOPAN。为了证实Cu-hemin/AOPAN的成功制备,使用扫描电子显微镜(SEM)、傅立叶...
关键词:静电纺丝 氯化血红素 聚丙烯腈 铜离子 催化降解 
Artificial metalloenzymes enabled by combining proteins with hemin via protein refolding
《Chinese Journal of Catalysis》2024年第12期157-165,共9页Jingping Ouyang Zhenfang Zhang RenéHübner Henrik Karring Changzhu Wu 
In this study,we unveil a conceptual technology for fabricating artificial metalloenzymes(ArMs)by deeply integrating hemin into protein scaffolds via a protein refolding process,a method that transcends the convention...
关键词:Artificial metalloenzyme Protein denaturation Click reaction Protein refolding HEMIN 
Mitochondria-targeted nanoparticles overcome chemoresistance via downregulating BACH1/CD47 axis in ovarian carcinoma
《Chinese Chemical Letters》2024年第5期344-350,共7页Ke Gong Jinghan Liao Jiangtao Lin Quan Wang Zhihua Wu Liting Wang Jiali Zhang Yi Dong Yourong Duan Jianhua Chen 
supported by the National Natural Science Foundation of China(Nos.82172736,81972886,and 82172735];the State Key Laboratory of Systems Medicine for Cancer(No.ZZ94-2306)。
The platinum-based chemotherapy is a routine strategy for the treatment of ovarian cancer,while it is prone to chemoresistance in clinical,which hinders the treatment.Therefore,it is urgently needed to elucidate the u...
关键词:Cisplatin-resistant HEMIN BACH1 CD47 PHAGOCYTOSIS ROS Synergistic effect 
Hemin blocks TIGIT/PVR interaction and induces ferroptosis to elicit synergistic effects of cancer immunotherapy
《Science China(Life Sciences)》2024年第5期996-1009,共14页Xiaowen Zhou Yang Li Xiangrui Zhang Beibei Li Shengzhe Jin Menghan Wu Xiuman Zhou Qingyu Dong Jiangfeng Du Wenjie Zhai Yahong Wu Lu Qiu Guodong Li Yuanming Qi Wenshan Zhao Yanfeng Gao 
supported by the National Natural Science Foundation of China(U1904147,31700677,U20A20369,82272785);Henan Provincial Science and Technology Research Project(232102311172);Shenzhen Science and Technology Program(KQTD20190929173853397);“Pearl River Talent Plan”Innovation and Entrepreneurship Team Project of Guangdong Province(2019ZT08Y464);the Guangdong Basic and Applied Basic Research Foundation(2022B1515120085);Fostering Project for Young Teachers of Zhengzhou University(JC22851042)。
The immune checkpoint TIGIT/PVR blockade exhibits significant antitumor effects through activation of NK and CD8^(+)T cell-mediated cytotoxicity.Immune checkpoint blockade(ICB)could induce tumor ferroptosis through I...
关键词:cancer immunotherapy TIGIT/PVR small molecule HEMIN ferroptosis 
Colorimetric and Photothermal Dual-modal Visual Detection of Iodide Ion Based on G-Quadruplex-Hemin Cascade Signal Amplification
《Chemical Research in Chinese Universities》2024年第2期305-310,共6页CHEN Yanyue LIU Jiali LIU Jiawen HU Rong YANG Yunhui ZHANG Xiaobing 
supported by the National Natural Science Foundation of China(Nos.21864026,21605130);the Natural Science Foundation of Yunnan Province,China(Nos.2018FB016,2016FD017).
The insufficient internal resorption of iodide ions(I−)leads to thyroid disorders,such as goiter,hypothyroidism,and cretinism in adults.In this paper,a portable point-of-care testing(POCT)platform was developed for th...
关键词:Dual-modal platform G-QUADRUPLEX Iodide ion Point-of-care testing(POCT) APTASENSOR 
Hemin-functionalized polypyrrole/paper-derived biochar electrocatalysts:Enhanced sensor platforms for H_(2)O_(2)
《Progress in Natural Science:Materials International》2024年第2期280-289,共10页Yuhang Jiang Tianshuang Bao Xiangchuan Zhao Qi Wang Yue Cao Jun Cao Xingxiang Ji Weimeng Si 
supported by the National Natural Science Foundation of China(51502161 and 21706148);the Natural Science Foundation of Shandong Province(ZR2020ME041,ZR2022QB173);Joint Zibo-SDUT Fund(2019ZBXC358);Foundation of State Key Laboratory of Biobased Material and Green Papermaking,Qilu University of Technology(Shandong Academy of Sciences)(KF2019-06)
As a H_(2)O_(2)electrochemical biomimetic enzyme sensor,the stability,repeatability and sensitivity of hemin-based composites are closely connected with the loading of hemin on high-performance matrix.Herein,polypyrro...
关键词:HEMIN BIOCHAR Paper-based carbon materials Paper-making process H_(2)O_(2)sensing 
Target-induced Trivalent G-quadruplex/hemin DNAzyme for Colorimetric Detection of Hg^(2+) Based on an Exonuclease III Assisted Catalytic Hairpin Assembly
《Agricultural Biotechnology》2024年第1期51-57,共7页Zhenghua LIU Zhonghai LI 
Supported by The Science and Technology Project of General Administration of Quality Supervision,Inspection and Quarantine (2015IK126);The Science and Technology Project of Changsha City of Hunan Province of China (KQ1602124).
Mercury ion(Hg^(2+)),a highly noxious of heavy metalion,has detrimental effects on the ecological environment and human health.Herein,we have developed an exonuclease III(Exo III)assisted catalytic hairpin assembly fo...
关键词:G-quadruplex/hemin DNAzyme Multivalence Catalytic hairpin assembly Exonuclease III Signal amplification Colorimetric detection 
基于Tb-OBBA-Hemin纳米酶测定人血清中左氧氟沙星含量
《广州化工》2024年第1期135-137,共3页叶强 
本文对分光光度法测定人血清中左氧氟沙星的条件进行研究,建立一种测定人血清中左氧氟沙星浓度的简单方法。通过左氧氟沙星增强Tb-OBBA-Hemin的拟过氧化物酶活性,在中性条件下,催化过氧化氢氧化TMB生成蓝绿色的ox-TMB,在保持过氧化氢、...
关键词:Tb-OBBA-Hemin 分光光度法 测定 左氧氟沙星 
Hemin对康乃馨切花瓶插寿命和生理效应的影响被引量:1
《安徽农学通报》2023年第12期45-50,83,共7页梁海英 张雪平 仰小东 
江苏省高等学校基础科学(自然科学)研究项目(21KJB220005);江苏开放大学“十四五”2021年度科研规划课题(2021-S-14);江苏基层社会治理研究协同创新基地研究成果。
本研究设置0.0005、0.0050和0.0500μmol/L 3个不同浓度的氯化血红素(Hemin),探究其对不同品种康乃馨的鲜切花保鲜的影响。试验结果表明,不同浓度Hemin处理均能显著提高3个康乃馨品种的瓶插寿命和观赏价值,其中以0.0050μmol/L的Hemin...
关键词:氯化血红素 切花康乃馨 保鲜 生理指标 
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