NUCLEOSIDES

作品数：53被引量：156H指数：6
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相关领域：理学更多>>
相关作者：李绍平朱荃詹华强季晖董婷霞更多>>
相关机构：南京中医药大学中国药科大学香港科技大学茂县农业局更多>>
相关期刊：《National Science Review》《Journal of Crystallization Process and Technology》《中国生物学文摘》《Chinese Herbal Medicines》更多>>
相关基金：国家自然科学基金国家教育部博士点基金教育部科学技术研究重点项目更多>>
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2′-Fluorinated nucleoside chemistry for new drug discovery:achievements and prospects
《National Science Review》2024年第10期362-379,共18页Yonggang Meng Nannan Sun Lan Liang Bin Yu Junbiao Chang 
supported by the National Natural Science Foundation of China(82130103,U1804283,81773570,22277110,82204209,and 82473761);the National Key R&D Program of China(2021YFC0864700 and 2022YFE0202700);the Central Plains Scholars and Scientists Studio Fund(2018002);China Postdoctoral Science Foundation(2023T160601);Henan Province Epidemic Prevention and Control Emergency Research Project(221111311400).
Fluorinated nucleosides are an important class of modified nucleosides that have demonstrated therapeutic potential for treating various human diseases,especially viral infections and cancer.Many fluorinated nucleosid...
关键词：fluorinated nucleosides antitumor activity antiviral activity drug discovery 
Characterization of HpnG as a Purine Nucleoside Phosphorylase in Bacteriohopanepolyol Biosynthesis
《Chinese Journal of Chemistry》2024年第19期2351-2356,共6页Xinhui Li Xiaoyu Zhu Yuting Zhong Wei Zhang Fener Chen Wenning Wang Wei Ding Qi Zhang 
supported by grants from the National Key Research andDevelopmenttProgram(2018YFA0900402,2021YFA0910501);the National Natural Science Foundation of China(21921003,32270070,32270050,U22A20451);the Funding of Innovative Research Team of High-Level Local Universities in Shanghai and a key laboratory program of the Education Commission of Shanghai Municipality(ZDSYS14005);West Light Foundation of The Chinese Academy of Sciences(xbzg-zdsys-202105).
Comprehensive Summary HpnG plays a crucial role in the production of ribosylhopane,a key intermediate in the biosynthesis of bacteriohopanepolyol.Despite early extensive studies,the precise function of HpnG has remain...
关键词：ENZYMES Enzyme catalysis NUCLEOSIDES BIOSYNTHESIS Natural products LIPIDS Phosphorolysis BIOTRANSFORMATIONS 
Ultra-highly selective recognition of nucleosides over nucleotides by rational modification of tetralactam macrocycle and its application in enzyme assay
《Chinese Chemical Letters》2024年第6期274-278,共5页Huan Yao Jian Qin Yan-Fang Wang Song-Meng Wang Liu-Huan Yi Shi-Yao Li Fangfang Du Liu-Pan Yang Li-Li Wang 
financially supported by National Natural Science Foundation of China(Nos.22174059 and 22201128);Hunan Provincial Natural Science Foundation of China(Nos.2022JJ40363,2022JJ40365 and 2022RC1230);the Excellent youth funding of Hunan Provincial Education Department(No.22B0460);China Postdoctoral Science Foundation(No.2022M721542)。
Artificial macrocycle with high binding selectivity in water is often challenging but urgently needed in various research and application areas.Herein,we report a new water-soluble biomimetic tetralactam macrocycle an...
关键词：Rational modification Biomimetic macrocycle Ultra-high selectivity Enzyme assay 
Chemical components in cultivated Cordyceps sinensis and their effects on fibrosis被引量：1
《Chinese Herbal Medicines》2024年第1期162-167,共6页Zhonghua Dong Xiao Sun 
supported by Shandong Provincial Natural Science Foundation(No.ZR2021QH296).
Objective:Cultivated Cordyceps sinensis powder has been used as clinical drug and healthy food to nourish the lung and kidney,which solves the problem of serious shortage of wild C.sinensis.This study aims to explore ...
关键词：anti-fibrotic effects cultivated Cordyceps sinensis ERGOSTEROL NUCLEOSIDES POLYSACCHARIDES 
A Nearly 20-Year Journey to Success of Azvudine for Antiviral Therapy被引量：1
《Chinese Journal of Chemistry》2023年第23期3349-3357,共9页Bin Yu Junbiao Chang 
supported by the National Natural Science Foundation of China(Nos.82130103 and U1804283);the National Key R&D Program of China(Nos.2021YFC0864700 and 2022YFE0202700).
Modified nucleosides,particularly those with 4'-modifications,are significant nucleosides used in antiviral treatments.The drug discovery campaign of Azvudine starts from 2′-deoxynucleoside,followed by extensive modi...
关键词：NUCLEOSIDES Azvudine HIV COVID-19 Antiviral agents Infectious diseases Drug discovery 
Catalyst-Free Regio-and Diastereoselective Synthesis of Heterocyclic Nucleosides in the Eco-friendly Solvent 2-Methyltetrahydrofurant
《Chinese Journal of Chemistry》2023年第2期167-172,共6页Xiaodong Gu Qingwei Du Weijian Song Jun(Joelle)Wang 
We gratefully acknowledge HKBU RC-Tier 2 Start-up Grant for financial support.
An efficient and practical synthesis of heterocyclic nucleosides is developed by a catalyst-free highly regioselective and diastereose-lective[3+2]annulation of a-purine-substituted acrylates with nitrones.The reactio...
关键词：HETEROCYCLE NUCLEOSIDE CATALYST-FREE ANNULATION Regioselectivity Synthetic methods Cycloaddition 
Simultaneous determination of ten nucleosides and bases in Ganoderma by micellar electrokinetic chromatography被引量：1
《Food Science and Human Wellness》2022年第2期263-268,共6页Feiya Sheng Songsong Wang Xiao Luo Jianbo Xiao Linfeng Hu Peng Li 
financially supported by the Research Committee of the University of Macao(MYRG2018-00239-ICMS and MYRG2014-00089-ICMS-QRCM);the Macao Science and Technology Development Fund(162/2017/A3);Guangzhou International Science and Technology Cooperation Project(File no.201807010044)。
Ganoderma(lingzhi)is a famous herbal medicine and edible supplement in oriental countries for a long history.In this study,a simple micellar electrokinetic chromatography(MEKC)method was established for the analysis o...
关键词：GANODERMA NUCLEOSIDES BASES Micellar electrokinetic chromatography Quality assessment 
Chemical and chemoenzymatic stereoselectivesynthesis of β-nucleosides and their analogues被引量：1
《Organic Chemistry Frontiers》2022年第6期1719-1741,共23页Hui-Jing Wang Yang-Yang Zhong You-Cai Xiao Fen-Er Chen 
support from the Fundamental Research Funds for the Central Universities(Grants YJ201853,YJ201805 and YJ202120);the National Natural Science Foundation(Grant 21907072).
β-Nucleosides are fundamental building blocks of biological systems and are widely used as therapeuticagents for the treatment of cancer and viral infections, among others. In the last two years, nucleosideanalogues ...
关键词：synthesis ANALOGUES NUCLEOSIDE 
Trimetaphosphate-induced chiral selection between amino acid and nucleoside using ^(15)N-^(31)P coupling NMR被引量：1
《Chinese Chemical Letters》2022年第2期821-824,共4页Jianxi Ying Ruiwen Ding Yumeng Zhang Bowen Han Yeting Guo Ning Wang Dandan Guo Yile Wu Junwei Huang Yan Liu Feng Ni Shaohua Huang Yufen Zhao 
supported by the National Natural Science Foundation of China (Nos.91856126,42003062,21778042 and 41876072);Scientific Research Grant of Ningbo University (No.215432000282);Ningbo Top Talent Project (No.215-432094250)。
Life on Earth uses a common set of L-amino acids(L-aa)to construct proteins and D-nucleosides(D-Nu)to form nucleic acids,which serve as the carrier of genetic information.Herein,we reveal the in-trinsic mechanism of c...
关键词：Chiral selection Amino acids NUCLEOSIDES Prebiotic chemistry Origin of life 
Development of an eco-friendly and fast HPLC method for quantitative analysis of four nucleosides in Cordyceps and related products被引量：2
《Chinese Journal of Natural Medicines》2021年第12期954-960,共7页QIAN Zheng-Ming WU Zi HUANG Qi WANG Chuan-Xi TAN Guo-Yin LI Wen-Jia SUN Wan-Yang LV Gen-Pin GAO Hao 
supported by the National Natural Science Foundation of China (Nos.81925037, 82073976, and 31700013);the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program (No.2017BT01Y036);Guangdong Natural Science Funds for Distinguished Young Scholar(No.2021B1515020065);the Young Elite Scientists Sponsorship Program by the China Association of Chinese Medicine (No.QNRC2-B06);the Dongguan Academician Workstation Project (No.DGYSZ-2018-03)。
An eco-friendly and fast HPLC method was developed for the determination of adenosine, inosine, guanosine and uridine in Cordyceps and related products(fermented mycelia of Hirsutella sinensis and Paecilomyces hepiali...
关键词：ADENOSINE INOSINE GUANOSINE URIDINE CORDYCEPS 
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