云南高校图书馆联盟文献共享服务平台- COFACTOR

COFACTOR: 作品数：50被引量：72H指数：4; 导出分析报告; 相关领域：生物学医药卫生更多>>; 相关作者：焦士会刘林初芹钱丽颖王祥民更多>>; 相关机构：北京奶牛中心新疆维吾尔自治区畜牧总站中国农业大学新疆农业大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金广东省自然科学基金制浆造纸工程国家重点实验室开放基金国家现代农业产业技术体系建设项目更多>>

Peptide bridging for cofactor channeling in fusion enzyme lowers cofactor input by two orders of magnitude: 《Chinese Journal of Catalysis》2025年第4期390-403,共14页Zehui Guo Yan Sun; 国家重点研发计划(2018YFA0900702).; Biocatalysis with nicotinamide adenine dinucleotide phosphate(NADP)-dependent oxidoreductases faces a challenge in improving the efficiency of the costly cofactor utilization.Although enzyme fusion can offer cofactor ...; 关键词：Peptide bridge Fusion enzyme NADP(H)-dependent oxidoreductases Cofactor channeling Cofactor regeneration

Enhanced cofactor recycling and accelerated reaction rate via liquid-liquid phase separation in dual-enzyme condensates: 《Chinese Journal of Catalysis》2025年第2期135-148,共14页Jiaxu Liu Jiaxin Chen Xiaoyan Zhang Daidi Fan Yunpeng Bai; 国家重点研发计划(2023YFA0913600);国家自然科学基金(22378120,22078096)。; Enzyme catalysis is a promising way to produce chiral products in a green and sustainable way.However,the high cost of cofactors and their relatively low recycling efficiency hinder the widespread application of enzym...; 关键词：Cofactor recycling CONDENSATE Proximity effect Intrinsically disordered region Enzyme catalysis

Extensions of the Graham-Hoffman-Hosoya Type Theorems for the Exponential Distance Matrices and q-Distance Matrices: 《Journal of Mathematical Research with Applications》2024年第6期723-734,共12页Jie WANG; Let G be a strongly connected directed weighted graph with vertex set{v_(1),v_(2),...,v_(n)},in which each edge e is assigned with an arbitrary nonzero weight w(e).For any two vertices v_i,v_(j )of G,the distance d_(i...; 关键词：distance matrices exponential distance matrices q-distance matrices determinants COFACTORS cofactor sums

Double-stranded DNA-nucleic acid dye complex-sensitized biocatalytic photosynthesis:Base pairing-switched regeneration of nicotinamide cofactor: 《Journal of Energy Chemistry》2024年第7期618-624,共7页Zhen Dong Yanying Wang Dan Li Peng Wu; the financial support from the National Natural Science Foundation of China (22274102 and 22325403);the Fundamental Research Funds from Sichuan University (2022SCUNL104);the Open Research Fund of School of Chemistry and Chemical Engineering,Henan Normal University(2022A02); Photo-biocatalysis,the combination of photosensitization and biocatalysis,is an emerging solution for sunlight-based renewable energy.It is thus important to develop light antennas with both good light har-vesting and...; 关键词：PHOTOSYNTHESIS DSDNA SYBRGreenI TICT 2-phenylpropanol

Engineering of cofactor preference and catalytic activity of methanol dehydrogenase by growth-coupled directed evolution被引量：2: 《Green Carbon》2024年第2期242-251,共10页Jinxing Yang Liwen Fan Guimin Cheng Tao Cai Jibin Sun Ping Zheng Shuang Li Yu Wang; supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDC0110201);the National Key R&D Program of China(2018YFA0901500);the National Natural Science Foundation of China(32070083 and 32222004);the Innovation Fund of Haihe Laboratory of Synthetic Biology(22HHSWSS00017);the Youth Innovation Promotion Association of Chinese Academy of Sciences(2021177);the Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project(TSBICIP-KJGG-008).; Methanol,produced from carbon dioxide,natural gas,and biomass,has drawn increasing attention as a promising green carbon feedstock for biomanufacturing due to its sustainable and energy-rich properties.Nicotinamide ad...; 关键词：Growth-coupled screening Methanol dehydrogenase Cofactor engineering Directed evolution C1 bioconversion

Identification of positive cofactor 4 as a diagnostic and prognostic biomarker associated with immune infiltration in hepatocellular carcinoma: 《iLIVER》2023年第4期188-201,共14页Liangliang Bai Guan Liu Gang Dou Xiaojun He Chenyu Gong Hongbin Zhang Kai Tan Xilin Du; Background and aims:Human positive cofactor 4(PC4)is associated with the development and therapeutic resistance of several malignancies.However,the role of PC4 in hepatocellular carcinoma(HCC)remains obscure.Methods:T...; 关键词：Hepatocellular carcinomaHuman positive cofactor 4 Prognosis Risk signature

Efficient production of 14α‑OH‑AD by engineered Mycolicibacterium neoaurum via coupled cofactor and reconstructed electron transport system被引量：1: 《Systems Microbiology and Biomanufacturing》2023年第2期358-369,共12页Chenwei Zhang Yanbing Shen Yuanyuan Gao Zehui Zan Min Wang; supported by the National Key R&D Program of China,Synthetic Biology Research(no.2019YFA0905300);the National Natural Science Foundation of China(21978221);the Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project(TSBICIP-KJGG-001-08);the Innovative Research Team of Tianjin Municipal Education Commission(TD13-5013);the Tianjin Municipal Science and Technology Commission(21ZYJDJC00030).; 14α-hydroxy-androst-4-ene-3,17-dione(14α-OH-AD)is an important precursor for the synthesis of steroid drugs with anticancer and carcinolytic activity.Initially,14α-OH-AD was mostly synthesized by whole-cell ferment...; 关键词：14α-hydroxy-androst-4-ene-3 17-dione Mycolicibacterium neoaurum 14α-hydroxylase Electron transportation Coenzyme regeneration

Creation of cytochrome P450 catalysis depending on a non-natural cofactor for fatty acid hydroxylation被引量：1: 《Journal of Energy Chemistry》2023年第4期31-36,共6页Qing Li Xiaojia Guo Xueying Wang Junting Wang Li Wan Haizhao Xue Zongbao K.Zhao; supported by the National Key R&D Program of China(2019YFA0904900);the National Natural Science Foundation of China(21877112,21837002,21721004)。; Cytochrome P450 enzymes catalyze diverse oxidative transformations at the expense of reduced nicotinamide adenine dinucleotide phosphate(NADPH),however,their applications remain limited largely because NADPH is cost-p...; 关键词：Biocatalysis Cytochrome P450 Directed evolution Fatty acid hydroxylation Non-natural cofactor Synthetic biology

Concurrent silencing of TBCE and drug delivery to overcome platinum-based resistance in liver cancer被引量：1: 《Acta Pharmaceutica Sinica B》2023年第3期967-981,共15页Senlin Li Siyu Chen Zhihui Dong Xingdong Song Xiuling Li Ziqi Huang Huiru Li Linzhuo Huang Ganyuan Zhuang Ran Lan Mingyan Guo Wende Li Phei Er Saw Lei Zhang; supported by grants from the National Natural Science Foundation of China (81874226 and 81803020);the “Three Million for Three Years” Project of the High-Level Talent Special Funding Scheme of Sun Yat-sen Memorial Hospital;the Guangdong Natural Science Foundation (2016A030313834and 2017A030313871,China); Platinum-based chemotherapy resistance is a key factor of poor prognosis and recurrence in hepatocellular carcinoma(HCC).Herein,RNAseq analysis revealed that elevated tubulin folding cofactor E(TBCE)expression is asso...; 关键词：Hepatocellular carcinoma Tubulin folding cofactor E CHEMORESISTANCE siRNA delivery RNA interference Nanoparticle Combination therapy NANOMEDICINE

Cofactor manipulation to drive biosynthesis of natural products: 《Synthetic and Systems Biotechnology》2022年第4期1073-1074,共2页Qidou Gao Mengyao Zhang Xiaobing Yang; This work was supported by supported by Natural Science Foundation of Shaanxi Province(2020JM-177);Chinese Universities Scientific Fund(2452018314).; Microbial production of value-added products is a promising alternative to plant-and chemical-based routes[1].However,only few of interested chemicals are producing at bulk scale with microbial cell factories(eg.artem...; 关键词：enable MANIPULATION INTERESTED

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