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黑色素瘤缺乏因子2炎症小体在非感染性肺部疾病中的研究进展: 《中国呼吸与危重监护杂志》2025年第2期147-152,共6页赵培郭石平; 山西省中医药管理局项目(2023ZYYC2037)。; 黑色素瘤缺乏因子2(absent in melanoma 2,AIM2)是一种主要的胞质双链脱氧核糖核苷酸(Double stranded DNA,dsDNA)传感器。AIM2由许多源自胞质细菌的dsDNA配体激活,例如新生弗朗西斯菌和单核细胞增生李斯特菌、DNA病毒、合成聚(dA:dT)...; 关键词：炎症小体单核细胞增生李斯特菌脱氧核糖核苷酸 DSDNA DNA病毒干扰素诱导重复序列

Terahertz Electric Field Induced Double Strand Breakage and Vibrations of dsDNA in a Gold Nanoslit: 《生物化学与生物物理进展》2024年第12期3279-3291,共13页JIANG Duan-Jie WANG Yan-Hong WU Jing-Zhi ZHANG Rui; 国防科技创新特区(02-ZT-008)资助项目。; Objective This work examines the impact of external electric fields at terahertz(THz)frequencies on doublestranded deoxyribonucleic acid(dsDNA)systems adsorbed on Au(111)surfaces in aqueous environments.Methods The in...; 关键词：molecular dynamics electric field THz spectroscopy gold surface low frequency motions

The role of the cGAS-STING signaling pathway in viral infections,inflammatory and autoimmune diseases: 《Acta Pharmacologica Sinica》2024年第10期1997-2010,共14页Ming-ming Wang Yue Zhao Juan Liu Rong-rong Fan Yan-qing Tang Zheng-yang Guo Ting Li; supported by Macao Science and Technology Development Fund,0058/2020/A,0018/2023/AMJ,011/AIJ/2020 and 0003/2021/AKP;Swedish Research Council(Vetenskapsrådet)2019-01884;Swedish Cancer Foundation(Cancerfonden)200680 Pj;CIMED FoUI-975445.; Pattern recognition receptors are an essential part of the immune system,which detect pathogen-associated molecular patterns(PAMPs)and damage-associated molecular patterns(DAMPs)and help shape both innate and adaptive...; 关键词：cGAS-STING signaling pathway type I interferon(IFN) double-stranded DNA(dsDNA) viral infections inflammatory diseases autoimmune diseases

利用Cas9TX实现非病毒TRAC定点整合制备T细胞: 《生物技术通报》2024年第9期190-197,共8页崔海洋谭淼全壮陈红利董艳敏唐立春; 北京鼎成肽源生物技术有限公司自筹(Y6)。; 【目的】Cas9TX是Cas9的变体,能够显著降低基因编辑过程中染色体易位,大幅提升基因编辑的安全性。研究Cas9TX替换Cas9实现基因定点敲入的可行性。【方法】首先,利用His标签蛋白纯化技术制备Cas9TX蛋白,并在细胞水平上通过绘制EC50和核...; 关键词：Cas9TX 定点整合 RNP DSDNA CRISPR/Cas9

Generation of Eco-Friendly and Disease-Resistant Channel Catfish(Ictalurus punctatus)Harboring the Alligator Cathelicidin Gene via CRISPR/Cas9 Engineering: 《Engineering》2024年第8期273-286,共14页Jinhai Wang Baofeng Su De Xing Timothy J.Bruce Shangjia Li Logan Bern Mei Shang Andrew Johnson Rhoda Mae C.Simora Michael Coogan Darshika U.Hettiarachchi Wenwen Wang Tasnuba Hasin Jacob Al-Armanazi Cuiyu Lu Rex A.Dunham; supported by USDA Grant(2018-33522-28769);Alabama Agricultural Experiment Station grant(AAES-AIR).; As a precise and versatile tool for genome manipulation,the clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)platform holds promise for modifying fish traits of intere...; 关键词：Genome editing ssODN DSDNA Antimicrobial peptide Reproductive confinement Aquaculture

Double-stranded DNA-nucleic acid dye complex-sensitized biocatalytic photosynthesis:Base pairing-switched regeneration of nicotinamide cofactor: 《Journal of Energy Chemistry》2024年第7期618-624,共7页Zhen Dong Yanying Wang Dan Li Peng Wu; the financial support from the National Natural Science Foundation of China (22274102 and 22325403);the Fundamental Research Funds from Sichuan University (2022SCUNL104);the Open Research Fund of School of Chemistry and Chemical Engineering,Henan Normal University(2022A02); Photo-biocatalysis,the combination of photosensitization and biocatalysis,is an emerging solution for sunlight-based renewable energy.It is thus important to develop light antennas with both good light har-vesting and...; 关键词：PHOTOSYNTHESIS DSDNA SYBRGreenI TICT 2-phenylpropanol

全自动免疫分析仪在检测SLE相关自身抗体中的应用价值被引量：1: 《中国设备工程》2024年第10期244-246,共3页罗春华郝杏飞柳邦源龚峰戴峻英周昕; 为了更好地指导临床对系统性红斑狼疮(SLE)的诊疗,本文分析研究使用全自动免疫分析仪检测两种主流方法学对抗核抗体(ANA)特定靶抗原/抗体的应用价值。随机从2022年7月~2023年7月该院收集的样本中选取272例作为研究对象,入组样本按要求...; 关键词：化学发光法磁条码免疫荧光发光法系统性红斑狼疮 DSDNA 全自动免疫分析仪

dsDNA与TiO_(2)(110)在溶液中相互作用的动力学行为和机制: 《原子与分子物理学报》2024年第1期154-160,共7页杨晋胡书环刘雯孟范超; 广东省基础与应用基础研究基金(2020A1515011069)。; 金红石型TiO_(2)(110)在DNA传感领域具有广阔的应用前景,然而其与DNA在溶液中相互作用的动力学行为和机制尚不清楚.利用分子动力学模拟,深入研究了双链DNA (dsDNA)在初始时沿轴向平行或垂直于金红石型TiO_(2)(110)表面时二者在溶液中的...; 关键词：过渡族金属氧化物 TiO_(2) DSDNA 相互作用机制分子动力学模拟

基于dsDNA-CuNCs的荧光ELISA检测牛奶中的E.coli O157:H7被引量：2: 《食品与机械》2023年第9期38-43,94,共7页曹文凯山珊刘道峰彭娟邢克宇赖卫华; 国家自然科学基金地区项目(编号:82260644);江西省高层次高技能领军人才培养工程项目(2021年度)。; 目的:建立了一种灵敏检测牛奶中大肠杆菌O157:H7的新型荧光酶联免疫吸附方法。方法:以碱性磷酸酶水解焦磷酸盐-Cu^(2+)配位复合物,释放出Cu^(2+)形成铜纳米簇作为信号报告探针,通过对关键因素Cu^(2+)浓度、焦磷酸盐浓度、DNA模板的浓度...; 关键词：酶联免疫吸附铜纳米簇大肠杆菌O157:H7 检测

Adsorption dynamics of double-stranded DNA on a graphene oxide surface with both large unoxidized and oxidized regions: 《Chinese Physics B》2023年第1期598-605,共8页吴梦娇马慧姝方海平阳丽雷晓玲; Project supported by the National Natural Science Foundation of China (Grant No.11974366);the Fundamental Research Funds for the Central Universities;China;the Supercomputer Center of the Chinese Academy of Sciences;the Shanghai Supercomputer Center of China。; The adsorption dynamics of double-stranded DNA(dsDNA)molecules on a graphene oxide(GO)surface are important for applications of DNA/GO functional structures in biosensors,biomedicine and materials science.In this work...; 关键词：double-strand DNA(dsDNA) molecular dynamics simulation adsorption dynamic graphene oxide

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